Enbrel may seem great, but it has its dangers. After years of suffering with Ankylosing Spondylitis (AS), I was placed on Enbrel, which made my symptoms disappear. I was able to do all the activities the AS had kept from me. However, after a few years, I started having a lot of numbness and strange sensations in my legs and arms. It turned out that I was suffering from demyelization of the central nervous system, which is one of the "rare" side effects of biologics such as Enbrel and Humira (it's rare until it hits you!). I was pulled off Enbrel immediately. The nerve problems got worse, and then, after MRIs and a spinal tap, I was diagnosed with MS.
Read the warning labels that come with Enbrel! It states that some users have suffered from demyelization of the central nervous system. The chance seems rare until it happens to you! I'm worse off now than before starting Enbrel.