Posted 5/24/2013 11:21 AM (GMT -6)
I'm on 25mg mtx weekly, by injection. I take 5mg of folic acid every day except the day of the mtx. It has no effect on how much hair I lose - I still lose heaps. Having said that though, I don't suffer from any other side effects any more. No nausea etc. My GI (I take it for my Crohn's), who also happens to be a leader in research here in Australia, has told me the reason he recommends not to take it on the same day as the mtx is because mtx is a folate antagonist, meaning it interferes with folate metabolism. The theory then is that if you take the folate on the same day as the mtx, the folate will not be absorbed correctly and it could potentially interfere with the absorbtion of the mtx.
Of course, we all do things differently around here and we all should abide by what our Dr's tell us to do. And I agree with Chartreux that I do not wish to offend anyone or their Dr's by my post. All I can do is tell my experience.
Best of luck.