Weight Gain? Plaquenil or Enbrel??

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

New Member

Date Joined Nov 2016
Total Posts : 1
   Posted 11/9/2016 10:10 AM (GMT -7)   
I have been on Enbrel & Plaquenil for over 10 years, I have been off prednisone for about 5. I cannot lose the initial weight gain (65lbs) from methotexate/prednisone combo waiting to be approved for the Enbrel. I have had my thyroid checked, gym 6 times/week, follow strict diet. Nothing seems to work, so I ask could it be the medication/s?

Regular Member

Date Joined May 2012
Total Posts : 280
   Posted 11/10/2016 2:00 PM (GMT -7)   
I understand I read that a lot of folks have lost weight on the plaqunil. NOT me. I have been on it for about 4 years now. Prednisone too. I too have gained at least that much weight. I'm down to 1mg of predisone a day. But I have started gaining weight again. I am now on xeljanz I'm praying that is not causing it. I'm sorry that has happened. I am sick of myself.
Rhuematoid Arthritis, degenerative joints, herniated disc's in back and neck. Changed from Cimzia to Orencia injections now off Orencia started Rituxan infusion as of May 2014, Plaquenil 400 mg daily, 20 mg. prednisone, hydrocodone for pain. And like most of you I fight with fatigue regularly...

Veteran Member

Date Joined May 2013
Total Posts : 548
   Posted 11/11/2016 6:14 PM (GMT -7)   
I was on enbrel for 12 years or so. I gained weight and couldn't lose it no matter what I did. I don't know why it isn't accepted as a side effect because I went from 170lbs to 200 on it and the only time I lost it was when I was having really bad flares.

My theory is that all the immune suppression plays a role in it.

New Member

Date Joined Jan 2017
Total Posts : 1
   Posted 1/17/2017 3:21 PM (GMT -7)   
I've been taking plaqenil for just over a year now, the first few months I dropped 12 pounds and felt pretty good but since February last year the pounds have been creeping back on and when I got to September last year I've gained so much weight. 30 lb altogether to this day, I feel awful and uncomfortable, I eat very well and go to the gym 5 times a week but can't seem to lose any or stay at one weight.

New Member

Date Joined Jan 2017
Total Posts : 6
   Posted 1/19/2017 5:19 AM (GMT -7)   
Your body is dealing with a whole lot of new and frankly pretty terrible stuff when you have a chronic illness. I, personally, think it is more important to keep attuned to what your body wants and needs when it is broken like this, rather than forcing yourself to be just like you were before.
The weight gain may be related to the meds, it may be related to the inflammation in your body, it may even be due to stress or another autoimmune condition which hasn't been dealt with yet.

Prednisone definitely causes weight gain and weight redistribution. I've not been on that, but I am fat and I've been fat my whole life, even when I was working a job which had me walking the length and breadth of Manhattan my weight stayed constant.

If going to the gym makes you feel good, makes you proud and excited that your joints are cooperating and you aren't fatigued that's an amazing thing! That's something to be celebrated! But if you are fighting fatigue and joint pain to force yourself to work out because you want to lose weight.... That's less positive.

This may seem like a radical viewpoint (I'm sure some doctors would think so) but people can be happy and as healthy as possible for themselves at any size. Significant weight loss is difficult, and fewer than 5% of people keep that weight off for over a year or two. Take weight watchers, for example, touted as a super successful program. They count anyone who loses 10% of their body weight (so 20lbs on a 200lb person, clinically but likely not visually significant) who keeps the weight off for a matter of months to be a success. And let's say someone reaches their goal weight on weight watchers, regains that and more over three years, comes back and loses it again? That person is counted as a success twice!

It's hard to think that significant weight loss can be well nigh impossible, because we are so conditioned to see fat people as lazy and bad and out of control, and if we accept that maybe it's just a mostly genetic body type, like autoimmune conditions are mostly a genetic happenstance, we as a society have to address the fact we've been demonizing people based purely on their appearance.

You have an autoimmune condition. Your body is so much more complex that energy in/energy out (everyone's is, but especially chronically ill people.) Keep going to the gym and making yourself feel stronger and better, but try if you can not to make weight loss goal. Eat when you are hungry, eat what satisfies you and makes you feel good, move because it is pleasant to do so.

Though the title and some of the tenets are inherently flawed, you might want to check out Health at Every Size. It's written by a doctor who had been studying the negative terrible doomsday properties of obesity and found . . . It isn't actually bad.

We have so much to deal with as rheumatoid arthritis patients. Getting stressed over weight gain, distancing ourselves from our bodies even more than we already are by pain or dysfunction, will just exhaust us further mentally and physically.

celebrate life
Veteran Member

Date Joined Dec 2014
Total Posts : 2082
   Posted 1/27/2017 12:39 AM (GMT -7)   
I was dx'd with RA prior to menopause. None of the medications, even prednisone, seemed to affect my weight. I've always been in the normal for my height range. But menopause changed all that. Over the course of two years I've gained 20 lbs and have stabilized at that weight for a couple of years now. I didn't change my eating or exercise routine (zumba at least three times a week). The extra weight has affected my back and I have a lot of sciatic pain now. I'm hoping to lose it, but haven't yet given up my "sweet tooth". I don't eat donuts or drink soda and I eat healthy, but I still have chocolate of some sort every day. I have stopped eating a lot of candy too. I used to be able to get away with that.
If you have recently or are going through menopause (Don excluded here) that may explain some of the body mass changes.
New Topic Post Reply Printable Version
Forum Information
Currently it is Thursday, December 14, 2017 9:51 PM (GMT -7)
There are a total of 2,905,620 posts in 318,876 threads.
View Active Threads

Who's Online
This forum has 158231 registered members. Please welcome our newest member, BBGyrl.
265 Guest(s), 1 Registered Member(s) are currently online.  Details