anti CCP > 500 but pain is minimal.

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Date Joined Jan 2017
Total Posts : 1
   Posted 1/13/2017 3:15 PM (GMT -7)   
Hello. I was just diagnosed with RA. all my numbers look normal except my CCP Antibody IgG is > 500 (where they same normal range is < 16). my arthritis pain is VERY low. when I get a cold it get a small flare up but other than that, I am able to play racquetball for a least 2 hours 6 days a week and can do regular activities (job, wife, kids, evening school, etc..). My doctor just told me that I have a 90% chance of my RA coming to serious pain in 8 to 14 years and he is wanting to start me on 400 mg of plaquenil (hydroxychloroquine) and methotrexate (2.5 mg) four tablets a week. is anyone else doing regimine like this? Do you all know of other sites for people with my similar issues??

New Member

Date Joined Jan 2017
Total Posts : 6
   Posted 1/13/2017 9:41 PM (GMT -7)   
Hey there. I'm 29, I was diagnosed with RA about a year ago also with quite high CCP. I was on plaquenil and sulfasalazine for about nine months, and just this week switched from sulfasalazine to methotrexate. Honestly, I wish I'd started on the mtx from the beginning! Even though you don't feel pain right now (which is excellent) you still have an inflammatory autoimmune condition, and current medical practice is to treat RA aggressively when first diagnosed to help it into remission and hopefully avoid that serious pain ten years down the road! Doctors used to start with very conservative treatment and wait till there were radiographic symptoms in bones and major pain before prescribing methotrexate (which has been the gold standard for RA for at least fifty years) which didn't work.

If it makes you feel better, I'm four days into my first week of mtx and no side effects! It sounds like you're starting on a low dose, and if you take folic acid you shouldn't have a problem. The scary side effects are generally people taking a very high dose.

400 mgs of plaquenil is a standard dose for RA, and it works very well with methotrexate. Sometimes sulfasalazine is prescribed as well, but that would be down the road when and if your symptoms present more strongly. There are also the biologics (humira, for example, which you've probably seen ads for) which can be added to dmards, generally later on.

You can't drink alcohol on methotrexate, I'm not sure if that is an issue for you. If it is, you could discuss trying sulfasalazine first since you can have an occasional drink on that med, but for me at least it just wasn't up to the job!

( is another website with great articles and a forum which seems less active than this one but has excellent moderators who are super quick to respond.)

New Member

Date Joined Aug 2017
Total Posts : 1
   Posted 8/1/2017 8:31 AM (GMT -7)   
I have the same condition // high Anti CCP (528) but very low symptom just two swollen fingers and stiffness at my ankle in the morning.
My doctor treated me aggressively with 3 DMARD's ( MTX,Plaquenil and Cyclosporine ) because of the high level of Anti CCP.
He said my RA is very early I could have a chance to be in remission.
I just started the treatment for 3 months and don't know what the result is.
What about you now? I really want to know your story because we have the same condition.
Thank you.

New Member

Date Joined Aug 2017
Total Posts : 19
   Posted 8/2/2017 3:35 PM (GMT -7)   
Hello: my CCP has climbed up in the past year from ~25 to ~77 to ~147. I've been on 400 Hydroxychloroquine and 6 tablets mtx since last year. Last month, they upped my mtx to 8 tablets due to swollen hands. Pain so far is occasional but we'll see how it goes.

Stay positive, I'm told it helps if we lower our stress.
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