Hi everyone. My Mom has had RA for about
ten years now. She got on a pretty good regimen that included low dose methotrexate and 5mg prednisone. Unfortunately about
two years ago she stated getting low WBC count. She discontinued the methotrexate and her WBC came up, so they did not feel it necessary to to a bone marrow biopsy. She started on Plaquenil.
A few months ago her WBC came back dangerously low, a little over 1. She discontinued plaquenil and her WBC came up to 1.9. Her doctor recommended a bone marrow biopsy just in case.
Biopsy results are back. Her doctor told her she has myelodysplasia (or MDS) secondary to either the methotrexate or the plaquenil (or both). It's also known as preleukemia. It has a median survival rate of 2.5 years and a best case scenario of 5 years. Unfortunately, the kind of MDS my Mom has turns into Leukemia 100% of the time.
She asked if it is possible it could go away after the medications clear her system. Her doctor does not have any experience with MDS secondary to Methotrexate/ Plaquenil, so she said she does not know. This is new territory for her.
Does anyone have any experience with this?