Methotrexate question

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Regular Member

Date Joined Nov 2006
Total Posts : 116
   Posted 10/23/2017 8:44 AM (GMT -6)   
Recently officially dx’ed with RA. Took my first dose of methotrexate on Saturday. Both my rheumatologist and pharmacist told me that the side effects hit the next day. They told me nausea, vomiting, diarrhea, lethargy. So far I had a bit of an unsettled tummy, not nauseous just blah. Two quick dizzy spells yesterday. Just seconds really.

I am taking folic acid. And my dosage of methotrexate is four pills totaling 10mg. Will this be my “normal” on this med or is it a cumulative effect. The longer you take it the more side effects?

I am ecstatic that I didn’t get hammered yesterday, but I don’t want to count on same reaction each time and get blindsided one day when out with the kids.


Forum Moderator

Date Joined Feb 2003
Total Posts : 16408
   Posted 10/23/2017 9:44 AM (GMT -6)   
Hi Sarah, I checked at on the potential side effects of Methotrexate. They say the SE's will go away once the person becomes acclimated to it. You know there is always potential SE's with anything we take. Hopefully, you will just have minimal ones & be ok. I would think the dr will decide the dosage once he see's how you do with it.

Take care.
Moderator in Chronic Pain & Psoriasis Forums

New Member

Date Joined Aug 2017
Total Posts : 19
   Posted 10/31/2017 6:49 PM (GMT -6)   
Hello Sarah, I experienced that initially Methotrexate did not cause much nausea & unsettled tummy.

After about a few months in, it was my experience that the nausea increased, along with an upset tummy mostly on the day of and day after taking this medication. And the yucky feeling continues at my end...

Hope your side effects remain minimal, take care!


celebrate life
Veteran Member

Date Joined Dec 2014
Total Posts : 2109
   Posted 11/1/2017 12:31 AM (GMT -6)   
I am taking seven pills (one day a week), and folic acid, and so far I haven't experienced any side effects. I just wish it were controlling my RA a little better. I'm on Enbril too.
I remember reading a thread that a couple of rheumys suggested not taking folic acid on the day you take mtx, because it would interfere with the uptake of the meds. So I have been following that advice. I'm not sure if it makes any difference.

Regular Member

Date Joined Nov 2006
Total Posts : 116
   Posted 11/2/2017 6:20 AM (GMT -6)   
Thanks everyone. So far I am 2 doses in and no nausea or vomiting. I always have diarrhea so...... getting a barium enema for that soon. Fun.

One thing I have noticed is that I am more tired than normal. And fatigue easier. Really hoping that evens out down the road.

Haven’t seen any effects on my hands yet, but it’s early days.


Regular Member

Date Joined Oct 2014
Total Posts : 41
   Posted 11/2/2017 1:25 PM (GMT -6)   
Hi Sarah, I do not take Folic Acid on the day I take my six pills. They interact, but I don’t know how.

Rheumatoid arthritis, Fibromyalgia, Lyme disease, prolactinoma, bipolar I

Two roads diverged in a wood, and I—
I took the one less traveled by,
And that has made all the difference. ~ Robert Frost
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