Multiple Joint pains, negative to all the blood test except ANA

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New Member

Date Joined Jan 2018
Total Posts : 7
   Posted 1/11/2018 12:00 AM (GMT -6)   
Hi everyone,

I had suffered from chronic left arch pain.
I had been smoking for 5 years, about a half pack per day.

I stopped smoking but my pain became worse.
I felt pain in my left arch, left knee, achilles tendon (Bilateral)
Then my pain spread to knuckles of fingers (Bilateral), wrist

I had blood tests, and everything(C-Reactive Protein, HLA-B27, CK, C4 & C3 Complement, DSDNA, RA, Anti CCP, Scl-70) was negative and normal except ANA positive 1 : 160, homogeneous.

Also my doctor ordered X-ray for my knee, but normal radiograph was obtained.
She even said that there is no sign of inflammation or swelling.

I had red, dry eyes, and was seen by an ophthalmologist, but he did not see any inflmmation.

I have seen three rheumatologists and both of them concluded that I do not have lupus nor any other autoimmune disease.
Moreover, all of them examined the body parts but they did not figure out inflammation.

I also have been suffering from weird left rib pain, but X-ray was normal too.

However, my joint pain is improved but not gone totally, and since yesterday, it became worse again.
My left knee pain is chronic and I feel random joint pain (i.e. joint pain migrates - fingers - wrist - hip - elbow etc)
I was not given any medication other than Naproxen.

What should I do?
Should I request MRI for my knee and arch?

Is it possible to have RA even all the markers are negative? (Including RA, Anti CCP negative)

I am a 23 year old male, Asian, no family history of autoimmune disease.

Forum Moderator

Date Joined Jan 2011
Total Posts : 1074
   Posted 1/11/2018 1:41 AM (GMT -6)   
Hi not sure what Country you are from so weather you have good access to medical (insurance ect)
if you can get an MRI I guess that would help and to get blood tests re done as they can change
if you are not happy with your Rheumatologist you could seek another opinion or also go to a Physician they are sort of all rounder Doctors,
have they eliminated Lyme or Tick issues ? ( depending on your Country)
you can have RA with negative RF but usually the CRP will be up
and you can also get positive ANA and it being a normal thing so this can be confusing too
All you can do is Keep positive and keep seeking answers
FORUM MODERATOR Rheumatoid Arthritis for 30Yrs. Asthma,Fibromyalgia,Osteoperosis,Cervical Spondalosos,Degenerative Disc Disese,Disc Bulges, Diabetes,Heart SVT & AF, Sleep apnoea,Nocturnal Respiratory Failure,Panic Attacks,Anxiety
on; Methotrexate, Arava ,Endone,Targin 30mg (oxycontin),Prednisone, Metforman(Diabex) ,Tambocor.Oxygen & Cpap, Prolia-Injection,Lyrica,perindopril,rosruvistatin

New Member

Date Joined Jan 2018
Total Posts : 7
   Posted 1/11/2018 2:11 AM (GMT -6)   
Thank you BadDay,

I am from South Korea, but now I live in Los Angeles, California USA.

None of the doctors told me about Lyme.
I had simple blood test on 12/6 and more complicated one on 12/11.
dsDNA was weak positive from 12/6 result but negative from 12/11 result.

CRP, ESR, and other markers for inflammation was normal.

I saw my doctor 2 days ago and asked about whether I need redo the blood test, but she said no need to do so at this moment, may be after 3 months if pain still remains or worsens.

The most difficult part of visiting Rheumatologist's office over here is making a reservation. To see some popular doctors, 1 months minimum waiting time is normal.
Anyway, thank you for your answer.

Forum Moderator

Date Joined May 2014
Total Posts : 34666
   Posted 1/12/2018 1:46 AM (GMT -6)   
Hi minimize -

I see that BadDay asked you about Lyme. I think that was a good question.

The usual tests for Lyme disease are very unreliable.
Many of us with lyme do have a positive ANA.

If you're interested in more information - where to test for Lyme disease...and other information - come over to the Lyme forum.
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

New Member

Date Joined Jan 2018
Total Posts : 7
   Posted 1/12/2018 2:05 AM (GMT -6)   
Thank you Girlie,

I heard that the first symptom of lyme is its typical rash.
I never had such rashes before, though I had some other types of rashes caused by holter monitor pads.
Also doesn't it accompany fever? I went to doctors' offices nearly 10 times or more since last November but never had fever..

However I believe it is important to clear the possibility of lyme.. if you can, please let me know some of the tests. Or maybe I can request the test during my next visit.

New Member

Date Joined Feb 2018
Total Posts : 2
   Posted 2/12/2018 8:59 PM (GMT -6)   
I had similar problem. Lots of pain in multiple areas symmetrical. RA tested positive but all the inflammation tests were negative so rheumatologist said I did not have R A . Gave me NSAIDs and pain meds. Went on like this for several years. Had steroid injections in my spine for spinal stenosis....etc...

I stopped going to doctors because nothing helped and the pain was aweful and the doctor bills mounted high.
I just decided to try a new doctor. And what a difference a doctor can make. This guy actually listened.

He explained there are so many auto immune desease and many different types of arthritis. Inflammation is not always present on the tests. If you are in pain something is wrong.
Have you been tested for psoriatic arthritis? There are many different types of this form of arthritis and 15% of people who have this kind of arthritis never Had psoriasis.
He examined my finger nails and said I show signs of psoriasis on every finger nail... he is going to run more tests and x rays. Vitamin d deficiency can also cause you to have pain, so can anemia....
I hope you find a doctor that will take the time to help you.
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