Hi there, yes, I have PA (though, I think I might have Lupus....but, that's another story.) I have had very little results from most medications I've tried (and I've had one form or another of arthritis since I was a child.) Prednisone is a big no-no for me. Methotrexate made me feel awful, and I had a very tough time breathing while on it as well. My liver also conked out while on it - I came down with an acute case of EBV and mono that got me hospitalized. My liver enzymes were off the charts.
I did get some small relief from Azulphidine/sulfasalazdine, but I had to take a stomach buffer (prevacid) while on it - but that was not an issue for me since it helped and I could tolerate it. I actually took this in conjunction with methotrexate for a while.
Remicade stopped working for me after about 20 months and I started having allergic reactions. My liver, once again, conked out on me - luckily not nearly as bad as the first time. I'm supposed to start Enbrel someday, but am very hesitant after all this.
Since then, I have been on Plaquinil. Now, the write-up on it says not to take if you have psorisis and while on it, it has gotten slightly worse (knock on wood it won't get any more so.) However, my psorisis specifically has always been very mild, so even though I'm "worse" I know I'm still very (knock on wood) mild in the severity. Plus, oddly enough, the plaquinil IS doing something for me. I actually can feel it when I skip a dose - which tells me it's working. I feel much better once I get back on schedule with it. I've been on it since last May. I do still take a stomach buffer (Nexium now) as I do take a lot of Motrin off an on. It did give me stomach troubles when I first started it, but that did subside. And when I stop taking it (when I'm ill typically) I have to go through the tummy troubles when I start back up.
One note: the meds say it can affect your eyesight. I saw an opthamologist today who said he has yet to see anyone w/problems on the med making it sound like they used to give higher doses in the past which did. You should go see an opthamologist every 6 months to be safe.
Welcome, by the way. I, too, have been out of work for a year. My SDI claim has been denied twice. My doctor has told me if I can't find part-time where I can work from home at least 50% of THAT time to forget about working. My body can't seem to handle the stress of working, let alone life. I've lost 3 jobs due to illnesses (caused by such a weak immune system.) It is frustrating and depressing! I'm only 35 and I have 2 little ones (well, 6 and 4 1/2) and I'm often too sick or in too much pain to even let them go outside and play with the neighborhood kids. I feel so rotten about it all. My 6 year old is so used to the house being a pig-sty that she thinks a few things picked up is "clean" even though there are piles and piles of stuff everywhere! Ugh!
Sorry to moan on your thread...I hope you can find something that helps relieve your pain. I can relate completely. **