thanks for responding. From what you've described about your current situation, it sounds like you most definitely have a CTD of some kind. My rheumatologist originally tested me (3 years ago) for ANA, RF, and a host of other things. Not sure what ENA is, though, or if he tested me for it? At the time, I only test positive for RF--negative ANA. Because the ANA was negative, he did not test for any more specific antibodies, but said that it is possible (albeit rare) to test positive for specific antibodies (e.g., the ones for polymyositis) but have an overall negative ANA. As far as the specific antibodies for lupus, individuals with MCTD normally never test positive for those antibodies, but only test positive for the specific antibodies for MCTD (anti-rnp). It all gets so very confusing to me, but every single case is different. My mother had MCTD, and she started out with exactly the same symptoms as me--positive rf, symmetrical joint pain, raynaud's. I don't think she ever tested positive for lupus, and it was years before she developed the antibodies specific to mctd. She was left without a diagnoses for a very long time. This is such a grey diagnostic area, and really a bad space for a patient to be in. NOt having a specific dx, regardless of the lack of a cure, can really take its toll in the long run. I hope you find your answers soon as well.
Current dx: Rheumatoid Arthritis
Suspected dx: Early Lupus/MCTD; Inflammatory Bowel Disease
Current Meds: Enbrel, Plaquenil, Aciphex, Ultracet, Zyrtec, Allavert-D, Zantac, Tylenol PM
Past Meds: Relafen, Vioxx, Mobic, Voltaren, Sulfasalazine, Entocort, Prednisone, Humira, Reglan