This is my first post. I had juvenile RA when I was 7 years old. The only lasting effects I am aware of is some limited motion in my wrists. I am 42 now. I had no symptoms again until about 5 years ago. I have been on Plaquinil 400mg/day, with very little side effects. I guess I have been in denial about what I have since the Plaquinil worked so well until about 6 months ago when the pain, swelling and fatigue increased. My rheumy has been really pushing for me to go on Mexotrexate injections once per week. But I have been stalling. I have heard that the side effects are terrible. Can anyone tell me what I am in for? Is deformation of joints inevitable? What are the side effects of Mex? How long can you stay on it? How long has it been on the market? I am really depressing myself by thinking about this. Can anyone tell me the truth?