I know this has been asked before, but I can't recall the answer. I'm currently taking plaquenil, enbrel, and mtx. The enbrel and mtx are a double whammy on the immune system, and I was wondering if there would be a benefit to getting the flu shot. They provide flu shots free of charge at my job, but I usually don't get one. I'd rather leave it for the people who really need it--there are a number of older people in my building. But with a compromised immune system, is it a good idea to get one anyway? Also, can you get the flu shot with my medications? I know there are some vaccines we are supposed to stay away from, but I don't believe the flu shot is one of them?