I've had great success with mtx combined with enbrel for my arthritis. Enbrel was halfway hitting the mark, but it wasn't until I went on the mtx about 3 months ago that my arthritis came almost completely under control. There is the possibility that I will have to stop taking mtx and/or enbrel, though, due to a possible tb infection--but probably only enough to be treated for the infection, and then I can start again if I want. As someone already pointed out, immune suppression is linked to tb, especially latent tb infections that are reactivated because of the immune system being suppressed. The tnf-inhibitors are famous for it--I don't know how common it is for mtx, but as an earlier posted warned, it happens.
Best of luck to you!
Current dx: Rheumatoid Arthritis
Suspected dx: UCTD/Early Lupus
Current Meds: Enbrel, Plaquenil, Aciphex, Ultracet, Zyrtec, Allavert-D, Zantac, Tylenol PM
Past Meds: Relafen, Vioxx, Mobic, Voltaren, Sulfasalazine, Entocort, Prednisone, Humira, Reglan