I have AS also. My hips, knees, tailbone and lower back hurt all the time. It will radiate up in to my middle back and shoulders depending on the weather, my amount of activity etc. I've been on methotrexate, which helped a bit, but couldn't afford Dr. visits every 6 weeks for blood tests. I've been on sulfasalazine, which really helped but gave me mouth sores so I'm allergic to it. The only thing I take right now is 4-325 mg aspirin 3x a day. It's not helping much anymore but celebrex and the like don't do anything. So, I'm kinda stuck.
I'm HLA-B27 positive. Spondylo means spine and itis means swelling. So the pain is mainly in the spinal area but like I said, it radiates down and up depending on what I do.
Good luck to you. I hope you find some answers.
"God grant me the serenity to accept the things I can not change, the courage to change the things I can and the wisdom to know the difference."
DX: ankylosing spondylitis, periferal neuropathy, chronic migraines/headaches, depression/panic attacks, bi-polar, hypothyroidism, hypoglycemia, sleep apnea
RX: synthroid, estradiol, prozac, lamictal, inderal la, klonopin, seroquel, imiprimine, aspirin, (relpax, maxalt, phenergan, esgic plus, xanax, PRN for migraine)
Surgeries: hysterectomy 1997, tonsillectomy 2001, deviated septum 2005, cataracts (both eyes) 2006