reaction to methotrexate.

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New Member

Date Joined Mar 2007
Total Posts : 1
   Posted 3/4/2007 11:25 AM (GMT -7)   
I have been on Prednisone for about 6 weeks (started at 15 mg/day and slowly reducing ; now at 9) and feeling better and better. My rheumatologist started me on Methotrexate last week ( 15 mg once a week), while slowly reducing the Prednisone. I've had a bad reaction: aches in joiints that never hurt before and a feeling of increased weakness. The worst time of day for me has been from about midnight to midmorning, when the symptoms faded. I have been feeling a bit better each day and am almost bact to where I was before I started Methotrexate. I'm afraid to take a second dose this week.
Has anyone had a similar reaction? Any suggestions?

Veteran Member

Date Joined May 2006
Total Posts : 1179
   Posted 3/4/2007 11:41 AM (GMT -7)   
hmmmmmmmm, cant say i have but i did start on a lower dose of mtx 8 mg i think for a month then 12mg for a couple more and then the big 20. as i weened off the pred i was in bad shape but i always thought it was the pred not the mtx? when is ur next rhuemmy visit? if u dont reduce the pred is the mtx ok? good luck! and welcome to HW!

New Member

Date Joined Mar 2007
Total Posts : 13
   Posted 3/4/2007 4:02 PM (GMT -7)   
I'm really new to this, just dx in jan, but i agree with yalinda it's prob the decrease in the pred rather than a reaction to the mtx. when my docs took me from 20 to 10 of pred my pain shot up so high i had to go back to the hospital in what they called a "pain crisis" the team of docs agreed that they took me down on the pred way too fast. now they won't do a decrease of more that 2.5 over a 2 week period, and even then we watch the pain closely. hope that helps. I know that just other's experiences is what i am looking for and it does seem to help.
Dx. RA Jan 2007
36yo mom of 2, professional (dr's can have RA too)

Veteran Member

Date Joined Dec 2005
Total Posts : 1782
   Posted 3/4/2007 5:02 PM (GMT -7)   
I've never experienced that on MTX and I've been taking it for over 2 years. I've never been on pred, but I have read others experiences and it sounds like the decrease in pred maybe increasing your joint paint. Perhaps the taper is too fast for you? I would definitely give the doctor a jingle to let him/her know. I hope you feel better soon.
"My "Trifecta" - CD, AS & RA...

Co-Moderator Crohn's Forum

Remicade every 6 weeks, Methotrexate weekly, Folic Acid daily

Veteran Member

Date Joined Mar 2005
Total Posts : 3148
   Posted 3/6/2007 4:44 AM (GMT -7)   
This could definitely have been rebound pain from pred withdrawel.
Tell your doc what happened.
Could be this round of MTX will be easier.
Also, maybe find out what you can do or what can be RX'd for pain while getting off of the pred.

Best wishes.
Arthritis Forum Moderator
Active Severe Rheumatory Arthritis. Crohns Disease. A.Chiari Malformation & right brain venous anomoly. Partial Complex Seizures (under control!). MVP & Tricuspid Valve Prolapse. Rheumatic heart & lung. Previous Lymes Disease for 10 years.
Meds: Remicade infusions 300mg Q3weeks; Intra-articular knee injections when needed; Mercaptopurine 50mgQD plus 75mg weekly; Mesalamine 4GramsQD; Prednisone 10mgQD mantainance; Entocort 9mgQD; Meclizine; Augmentin; Tigan 300mg; Reglan; LidoDerm Patches; Diazepam 5mg for AS back spasms; Rozerem 8mg; Dilaudid 4mg tabs for pain. 

Veteran Member

Date Joined Mar 2005
Total Posts : 3199
   Posted 3/6/2007 8:23 PM (GMT -7)   
Hey jshal, when is your next dose? How are you feeling?
Moderator of Arthritis/Epilepsy Forums
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