This has been my experience:
I can only tell you that if those meds "take" with your body, then they typically make your life turn around for the postive! You may experience some minor cold/sinus type symptoms more regularly, but you'll feel so much better overall that a few sniffles won't bother you.
I would give them a shot (no pun intended!) and see how they work for you w/o worrying about the side effects. If they cause a problem, you'll know and can stop the drug. And, honestly, if one doesn't work that does NOT mean another won't - it's very likely one may work better than the other or one may not be the right drug for you, whereas another will work wonders!
From what I understand, most side-effects are not permanent problems. The few things they list as possible severe side-effects, as we discussed here before, are tpically side-effects people w/our issues are typically more prone to getting as it is....and there is no study to show if when taking the meds increase that risk or the numbers just reflect the standard ratio of people who get secondary diseases from the disease itself. Did that make sense?
I took remicade and had great results. I stopped becuase my immune system could not handle it after a while and I became too ill to take it anymore. Mind you, I've always had a weak consititution when it comes to fighting illness and methotrexate helped land me in the hospital on my death bed. So, I'm a bit of an unusual case in that matter I think. However, to make my point - in both cases, I (thankfully) recovered.