hi & welcome Sunpuppy!
we share similar scenarios. i've done 2 years time both on enbrel and then humira.
with both meds...it seemed like once i hit close to that 2 year mark, the effectiveness was just not like it used to be.
the opinions of both my GI & rheummy were that yeah, they can plateau after years & a person could just become sorta' "immune" to it.
so i quickly moved onto Remicade. it's been a year & 1/2 now.
the likelihood of this "plateau" effect is less w/ Remicade as you can keep on increasing the dose! so...one can be on Remicade for many many years.
i never hit a remission yet w/ Remicade, however i do feel significant relief initially after the infusion.
hair? it's thinned & it kinda "chunks" out of my head when i brush it...but no biggie.
w/ your pain meds...take into consideration how long you've been on lodine; you may be a bit tolerant to it.
please keep us posted on how you're doing.
Arthritis Forum Moderator & Co-Pilot
Active Severe Rheumatory Arthritis. AS. Crohns Disease. A.Chiari Malformation. MVP & Tricuspid Valve Prolapse. Kidney Stones (oh joy).
Meds: Remicade 600mg Q3weeks; Intra-articular knee injections; 6MP; Mesalamine; Prednisone; Entocort; Meclizine; Azithromycin; Tigan; Reglan; LidoDerm; Diazepam; Diclofenac; Dilaudid; OxyContin.