I know this is an old thread, but my neurologist just ordered a lip biopsy to test for Sjogren's. I'm 27 and I was diagnosed with a UCTD in 2008, positive ANA but other subserologies negative. I developed peripheral neuropathy in all four limbs in Feb. 2009 thought to be small fiber neuropathy.
I had 2 positive QSART (sweat tests) consistent with small fiber neuropathy, and 2 EMGs were negative (tests for large fiber neuropathy). I also have dryness, although my rheumatologist hasn't had any Sjogren's specific tests done. But both neurologists I have seen suspect Sjogren's due to the small fiber neuropathy, which if related to an automimmune disease, pretty exclusively points to Sjogren's.
My other symptoms: fatigue, joint pains/arthralgias, muscle pain/cramping, TMJ, GERD, chest pain, VOR vestibulopathy, year-round allergies receiving weekly allergy shots, headaches, history of enlarged lymph nodes on 2 occasions, Vitamin D deficiency, elevated liver function tests, pituitary microadenoma (benign). I don't have flare ups really; I feel the UCTD symptoms the same level all the time for past 2 years.
I am currently on Plaquenil, Neurontin, Tramadol, Lexapro, Allegra-D. I have failed tx. with Cymbalta, Lyrica and Savella.
Anyways, so I found this thread because I wanted to know how other's experiences with the lip biopsy went.
Also, I am always wondering if others on this forum have autoimmune related neuropathy as well...
Take care everyone and best wishes.