I like the smaller disposable applicators - they are easy to keep in purse and car, and I guess in the long run I end up using them more often like I should.
But my main reason for using them is that I'm afraid carrying the multi-dose bottle around with me would mean it (accidentally) was no longer sterile, and I'm afraid of what kind of damage that could do!
I use the same brand in either size, so I didn't answer initially as I wasn't sure I understood the question. For me, it's the same drops, the size of the container/applicator is the only difference.
So it turns out to be a matter of convenience and habit!
Lynnwood, Lupus & Sjogren's Moderator, Dx: 2002DIAGNOSING LUPUS & HW's LUPUS 101
"Life is far too important to be taken seriously." - Oscar Wilde