centromere antibodies

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Date Joined Apr 2014
Total Posts : 66
   Posted 7/10/2016 8:00 PM (GMT -7)   
okay so in addition to having this rare form of autoimmune epilepsy and muscle twitching caused by anti voltage gate potassium antibodies i have antibodies to centromere. i was negative for centromere b which causes scleroderma but another test i took tested all centromere antibodies and it didnt tell me which ones it just said centromere and the level was 677 when normal was less than 100. this would have to be probably centromeres a or c.. the ana was also positive around 1 :160. so i have two autoimmune diseases. i guess they are both rare and most extremely rare together.

my question is does anyone have symptoms of sjorgens with centromere antibodies but centromere b negative? i was negative for the sjorgens antibodies. if you subtract the symptoms caused by the voltage gate antibodies which is the chronic muscle twitching and the epilepsy and inflammation in my brain i have just joint pain primarily with swelling in the elbows and dry eyes. my mouth doesnt get very dry just my eyes. occasionely my glands swell in my neck or around my face but mostly its severe joint pains without swelling except for the elbows. what can ache are the hips, elbows, wrist and neck and back pain. its never really in my knee or ankles that much.

i dont have a diagnosis for this problem they just wanted to start me on plaquenil. he said the ana and antibodies could be causing this. i feel like with my eye problems it sounds like sjorgens more than anything else but who the hell knows maybe i just have something that nobody else has :( if anyone can advice me or if they were diagnosed sjorgens with centromere antibodies let me know. i was negative for B but apparently way positive for one of the others.

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Date Joined Jun 2006
Total Posts : 1650
   Posted 8/1/2016 3:11 PM (GMT -7)   
Hi fnfiacco. The antibodies that are positive for Sjogren's are SS-A and SS-B and the test methodology (ELISA) is usually very specific for just those antibodies.

The centromere antibody test is usually run to help diagnose or rule out CREST or scleroderma and to my knowledge it is not at all useful in diagnosing Sjogren's.

I wish I had better information for you. Lots of folks have chronic dry eyes and if over the counter medications don't help, you may consider seeing an ophthalmologist (a physician who specializes in the eyes). Love, Butterflake
SLE '05, Sjogren's, Fibro, Raynaud's, major depressive disorder, CVID (Common Variable Immunodeficiency), Hypertension, Osteoporosis, CNS problems, GERD, angina, 1st stage kidney disease. Many meds: better living through chemistry
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