These meds perform in drastically different ways, they are not equal to each other.
Plaquneil is a disease inhibitor, slowing the progression of the disease. Usually this is prescribed upon initial diagnosis, and never stopped, no matter which of the other meds may be added to your treatment.
Then comes Prednisone, to help get inflammation under control.
Then comes one of the three, Imuran, Cellcept, and MTX (methotrexate) to treat disease activity.
None of these meds "treat the fatigue". What you probably have is inflammation and disease activity, which causes the fatigue. Once you treat the inflammation/disease and get it under control, the symptom of fatigue will lessen.
Meanwhile it is important to eat well, get deep restorative sleep, get some mild exercise, and avoid stress.
Only your rheumatologist knows the full picture of your symptoms and labs, along with how you have responded to treatment so far, to be able to suggest a particular medication that might be right for you.
Lynnwood, Lupus & Sjogren's Moderator, Dx: 2000DIAGNOSING LUPUS & HW's LUPUS 101
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