I think I've heard of Lupus and RA occasionally going into remission after methotrexate. Does primary sjogren's ever go into remission after methotrexate? Plaquinil isn't working for me anymore. Fatigue is my primary problem. Azathioprine only seems to help a little. My rheumy says methotrexate is my only other option. Right now I'm just kind of getting by mostly on tumeric and advil, but I'm not doing great. Any suggestions?