Has anyone had any luck with Pristiq ? I don't know what to do. This is the first time I've fallen back into depression so quickly. I was sort of OK and now I just can't handle it. I'm in school and obviously I have to cope, but it's getting harder and harder each day. If a medication were helping me, I would be OK with the side effects, but I just feel hopeless. My doctor has told me that if this doesn't work that there's only like a couple other options. This was not encouraging. I've definitely been on Lamictal and Pristiq long enough that they should be working, but I can't even get back to a state where I was coping. Now I'm an awful, dark, icky depression. I have this fear of failing, but spend more time worrying about work than actually doing it, I have an unrequited love 2600 miles away, and I can't get it together and stop being so depressed !!! I used to feel like I was looking for the miracle drug, but now I have very few options left which scares me. What if there isn't one ? What if this is just as good as it gets now ?