Increase or decrease generic Lamictal/Lamotrigine

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Regular Member

Date Joined Apr 2005
Total Posts : 82
   Posted 6/4/2010 7:04 AM (GMT -7)   
Hubby is BP now. For years he has been doctoring for anxiety/depression. But his new pdoc got him off Seroquel last fall. Since then he's been bipolar. He started taking Lithium in November but got bad shakes from it. So changed over to Lamictal over 6 weeks or more ago. It was working fine, but 2 weeks ago, increased it to 100mg at night and then also went to the generic Lamotrigine. Since then it's like he's not taking anything. He's back to his manic/depressive stage.

We saw his doc yesterday, he said to decrease back to 50mg/night. But after we got home, I'm wondering if maybe it should be upped to 150mg instead? Does the generic not work as well as the brand? His doc is gone now until the 17th.

I could deal with the anxiety/depression, but now with bipolar it is really hard. The moods, the emotions, the outbursts, the spending, misplacing things and more.

Regular Member

Date Joined Apr 2010
Total Posts : 255
   Posted 6/4/2010 10:57 AM (GMT -7)   
I've been on Lamictal for the step stages 25mg - 100mg
then was switched to the generic version which I've been taking for the last month.
I didn't notice a big change from one to the other. I did however just get my pdoc to up my dose from 100mg to 150. Because although I noticed it helped some, it wasn't enough to keep me stable if I stressed on anything.
I don't know if that helps but good luck.
Faith... is the art of holding on to things your reason once accepted, despite your changing moods.

Bipolar Disorder
Borderline Personality Disorder
meds: pristq, lamotrigine, ambien cr, Xanax

Veteran Member

Date Joined Jan 2010
Total Posts : 2896
   Posted 6/4/2010 3:45 PM (GMT -7)   

My pdoc just told me something about this at my last appointment.

The margin of error for the amount of medicine is twice a much for generic than for brand name.  So if the dose from the brand name drug was just *barely* enough, the difference from the wider margin of error in the generic could be that the dose is effectively too low.

Margin of error for brand name is 0.5%.  For generic is 2 - 3 %.

Bipolar 2
Borderline Personality Disorder
Post Traumatic Stress Disorder
Panic Disorder

Regular Member

Date Joined Apr 2005
Total Posts : 82
   Posted 6/7/2010 11:11 AM (GMT -7)   
We did reduce it on Sat. I don't know if that is right but he hasn't gotten worse - yet. He also takes Temazepam, 30mg, Zanax 2mg, clonzepam 1mg, and Trazadone 400mg.

Most of those are just for him to get to sleep at night. The trazadone he has at morning and noon, 100 ea then 200 at bedtime.

So tortoise11, what you are saying the generic Lamicatal should be increased alot. If he doesn't improve by next weeks dr appt, I will suggest to increase. Maybe there is another one he can try that will help more.

Hubby also says his vision is blurry. He gets obsessed with things, and I think that is one of them. I can't get it across to him, his reading glasses will not work for wearing for distance. He claims he should be able to wear them all the time.
It's times like this it is hard to know what to do.

horse crazy
Regular Member

Date Joined Feb 2010
Total Posts : 199
   Posted 6/11/2010 10:13 PM (GMT -7)   
Been on Lamictal (200mg) for 5 years and was switched to the generic I am not sure when. but I didn't notice any difference. Be carful about changing doese on your own. In figuring out doses the pdoc takes ALL the medications into account where as we tend to look at just the one drug by itself. I know how desperate you can feel when symptoms return or get worse. Try to hang in there unyil the 17th when the pdoc returns. Your husband's bread through of symptoms might or might not be related to the lamictal. I know when I suddenly get hit with symptoms that had fallen off the radar, I can desperately start manipulating my medication to try and restore status quo. That rarely works and I need the help of my pdoc to help me level out again. That is what is so challenging about BP...certain meds seem to really work, all is fine and then out of the blue you are a unstable mess.
Horse Crazy
Bi-polarII; rapid cycler; Lithium 600
Requip XL 8mg; Lamictal 200 mg; seraquel 450mg, klonopin 4mg

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