Haven't been on healingwell in quite awhile, and have run through a series of different drugs since I last posted. Almost all had negative results. Been on lamictal for several months now, with generally positive results, and very low doses of Rexulti two days a week - though the combination is only ok so far at reducing my depression to some degree. Due to the encouragement of both my psychiatrist and psychologist, I decided to go the GeneSight route. The results I received pretty much explained everything about my treatment regimen for the last decade. Out of all of the ADs on the market, I only had two in the "take as directed" column. All the other ADs were either in the moderate drug-gene interaction or the significant drug-gene interaction (most of them were in this column). Surprised, but not surprised. As well, every AD that is used for OCD, which I also have, was in the significant column. It appears I have a genotype that does not metabolize a whole series of meds, which includes most of the ADs, and a lot of antipsychotics (which was the second regimen my pdoc was trying because we were having such problems with the ADs). Unfortunately, Rexulti is in the significant column, so things will have to change there. The only areas in which I "passed" were with the mood stabilizers and the hypnotics/anxiolytics, which at this point, I have had very few problems with. Another revelation from the report is that I have a short form of the serotonin transporter gene, which makes SSRIs pretty much useless for me. Alternative treatment regimens were suggested.
The most interesting thing about the results is that they go a long way toward explaining my troubles with meds over the years. I expected to gain some insights into my treatment, but I didn't expect to get results that mirrored my treatment issues so closely.
I see my pdoc next week to go over the results, and hopefully we will come to some path forward based on the genetic test results.
As a scientist, I realize the gene test results are not going to be perfect, but they will at least serve as a road map for future treatment plans. That is much better than total trial and error, which is what I have been doing for much too long.