Depakote advice needed

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New Member

Date Joined Mar 2007
Total Posts : 8
   Posted 3/17/2007 6:45 AM (GMT -7)   
Hi all,
I just got out of the hospital and diagnosed with bipolar II.  The psychiatrist in the hospital put me on zoloft in the morning and depakote in the evening.  I'm new to depakote obviously.  Just wondering if any of you could share your experiences on depakote.  It seems to be working for me.   I definitely feel a lot more even keeled than ever in my life, but if there is something even better out there I'd like to ask the doc about it.  Also, what are the long term effects of being on depakote for those of you have have been on it for awhile?

Regular Member

Date Joined Jan 2007
Total Posts : 21
   Posted 3/17/2007 11:09 AM (GMT -7)   
I', currently on depakote and let's just say sleep wasn't a option. No matter when I took it, it would put me to sleep during the day and keep me up at night. However good news, we, dr and me, lowered the dose and now it works just fine. I can sleep again :) I personally love how the depakote treats my moods. Although I am on other meds I think the depakote worked the fastest and best so far.

Are you having a good day :) or a bad day :(
Either which way glad to meet you. :D

New Member

Date Joined Mar 2007
Total Posts : 8
   Posted 3/17/2007 7:20 PM (GMT -7)   
Thanks Butterfly.  Hopefully it will keep working for me.

Regular Member

Date Joined Feb 2007
Total Posts : 87
   Posted 3/18/2007 5:01 AM (GMT -7)   
HI butterfly.

I'm new to this forum - I have been in the Lyme forum for a few months now. My Dad is Bipolar and took Lithium for several years. There was a mix up at the MD office and they gave him 2 BP meds plus lithium and his system got completely out of whack. He has been taken off the lithium and was given Neurontin.

I did some research and saw that Depakote would be the best choice after lithium, or one of the best.

He seems to be doing OK - some good days and some bad. The bad ones worry me because he seems really depressed. He aslo has to take a sleeping pill to get a halfway decent nights sleep.

Has anyone here had any dealings with Neurontin?

Regular Member

Date Joined Feb 2006
Total Posts : 152
   Posted 3/20/2007 7:01 PM (GMT -7)   
I sure hope neurontin isn't your only stabilizer. I wouldn't trust it alone to keep anyone stable. I mean, it's a great med for what it's approved for- neuropathic pain, and... I dunno what? I've taken it before but couldn't handle it. It just made me feel really sick.

I know that neurontin is popping up as a drug of abuse in some places. Only abuse I could see is how it abuses my stomach. Because of that, it's newer cousin, Lyrica is scheduled, but it makes me super sick as well.

If you can tolerate either of them, Lyrica will probably turn out to be a better mood stabilizer, in my opinion. It's just too early to tell, and there hasn't really been any anecdotal evidence, and with the C5 logo on the bottles, it's less likely docs will prescribe it off label for those uses.

Depakote is usually the next choice after Lithium fails. Neurontin as the second choice makes me think his bipolar must not be very severe- is that correct?

But who knows. I've been on so many meds I have no way to keep track. Depakote, Lithium, Geodon, Seroquel, Risperidone, Zyprexa, Lamictal, Topamax- plus a whole lot more. I know I'm barely scraping the surface, and those are just the bipolar meds. Then there's the ADD stuff- which was really just Concerta and then Adderall, the Anxiety meds, klonopin, valium and ativan, bupropion (yuck yuck yuck yuck yuck!!!!! I hate that garbage!- It caused the worlds worst panic attacks!!)

God, I hate bupropion. I was deer hunting, alone, and just shot a smallish buck. Immediately as I stand up to walk towards the deer, I start floating outside of my body- my heart was racing and I started to get dizzy. For a second everything I was looking at became very distant, stretched out a lot, and then sorta snapped back in place. Then I fainted for a few seconds, felt sorta like Orthostatic Hypotension (blacking out when standing quickly after sitting). Never ever will I take it again. After that happened, I felt really wired, angrily manic in a way, and just out of tody with my body in general.

You'll do well- just make sure that your relationship with your doc is a two way street. Too often people are bullied into taking meds they don't want to take by their doctors.

You should have the right to choose your own medications. My first psychiatrist, whenever we needed to pick something else for me, would give me a list of everything that was used to treat the problem we were dealing with, and then I had complete control over it.

Obviously, with some things like ADD and Panic, you have less say since you're dealing with controlled substances, but you should always have the final say no matter what.

New Member

Date Joined Aug 2007
Total Posts : 3
   Posted 8/9/2007 9:13 PM (GMT -7)   
Depakote worked wonders for me.. I started to feel more balanced out within days and felt a WHOLE lot better after only two or three months. My mixed episodes ended after about two months and I don't think I've been depressed for longer than a few days in 2 years

New Member

Date Joined Aug 2007
Total Posts : 3
   Posted 8/11/2007 7:29 AM (GMT -7)   
Depakote made me feel like Homer Simpson. I didn't get bothered by anything? The down side is kidney and liver problems long term. I ran out 2 and a half years ago and the doc took that as an opportunity to try alot of other meds. I am on Remeron now and that to me feels better than Depakote and I have no sleep issues. Just very lowered sex drive. Seroquel really was the worst med for me. Felt like I could sleep anytime of the day or night. I also take Gabapentin (nerontn?) and no stomach issues so far. Depakote isn't a bad drug as long as you monitor your liver and kidneys. K
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