Classical lobular carcinoma patients?

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New Member

Date Joined Sep 2005
Total Posts : 2
   Posted 10/2/2005 3:07 AM (GMT -7)   
My friend had a mastectomy recently.  Her diagnosis, classical lobular carcinoma, with LCIS.  Multiple nodules were found, the largest tumor being 3.5 cm, over three quadrants.  I'm glad she elected to have the mastectomy.
She appeared to be node negative, but closer pathology revealed a small sentinel node met, but 14 or 14 additional axillary nodes were negative.
She is ER+ at 70% and PR+ at 20%.  BRCA 1 & 2 negative, Her2/neu negative.
She is being offered dose dense A/C if she wants it, (and ovarian suppression or ablation), followed of course by Tamoxifen (she is premenopausal.)
Anyone who knows lobular knows that her best bet is hormonal therapy, but she is struggling with the risk vs. benefit of chemo.  The benefit for lobular patients is low, and even then researchers and doctors are uncertain whether any real benefit exists from the chemo itself or whether the ovarian suppression induced by chemo is what offers the small (2-8%) benefit of A/C for these patients.

Oncotype DX assay results are forthcoming.

Meanwhile, is anyone else here in a similar situation?
Thank you.

Veteran Member

Date Joined Jul 2003
Total Posts : 2921
   Posted 10/3/2005 5:56 AM (GMT -7)   
My friend had lobular, had 23 of 25 nodes positive. She had chemo. Later she had a second mastectomy to remove the mirror chances and then had Bone Marrow Transplant. She did well for about 12 years and then had a recurrence in her neck nodes. Radiology kept that from getting worse, but finallyl the cancer showed up in her liver and other organs. She took Tamoxifen, also. I think your friend needs to find the best doctor she can that she trusts and follow his/her advice. Even with that there is no guarantee. Tell her about this site and we will help her all we can. Hugs MK

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