This is a really old forum, so I'm not sure if anyone will even read this but I, too, had CMV & Mono simultaneously in high school. I have no idea how I caught it because I was such a nerd in high school and certainly wasn't kissing anybody, haha. But anyway, I can remember waking up one day and just very suddenly feel AWFUL. My throat hurt worse than it ever had before everrrr. Which says something because I had chronic tonsillitis in middle school and had my tonsils and adenoids taken out. The only way I could describe it to my doctor was comparing the feeling to those performers who swallow fire or can swallow swords etc. I literally felt like my throat was on fire. Eating hurt so bad I cried at every meal for upwards of 2 or 3 weeks. I ended up losing a looott of weight because all I could stand to eat was soup. I was unbearably fatigued. I could sleep in until noon, having gone to bed at 10, and wake up feeling like i needed to sleep more. My glands were extremely swollen. My whole body hurt, so achey.
But anywayyss, you weren't asking about having them currently you were asking about long-term. I was diagnosed with CMV/mono, the combination from hell, when I was 16. I am 21 years old currently and I don't feel like I have ever fully gotten back on my feet. I am always tired. I have been treated with anti-depressants, because as you can imagine being tired and sick all the time interfered with my schooling and my relationships, as well as NuVigil/Provigil that is intended to boost energy. All my blood tests would come back clear and okay, with the exception of cmv and mono antibodies being present. I got so tired of the "you're faking it, lazy college kid" look from doctors. Finally when I was referred to an infectious disease specialist, Dr. Duncan, I was diagnosed with fibromyalgia (at 18!!?) and CFIDS (chronic fatigue immuno-deficiency syndrome) and was put on Lyrica for the body aches. I took Lyrica for a while but I ended up gaining about 25 pounds over the course of a couple of years without changing my life style at all. It also make me even more tired which interfered with normal life...again.
After a wholeee bunch of trial and error...I finally feel okay. Not as energetic as I was pre-mono/cmv, but that could just be growing up. I'm now on Savella (marketed for fibromyalgia but technically an antidepressant), Wellbutrin XL (anti-depressant), and trazodone (anti-anxiety) all those are for other issues but I've never felt bettter.