Is Gilbert syndrome a new risk factor for breast cancer?

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zandor
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Date Joined May 2008
Total Posts : 15
   Posted 6/19/2012 1:32 PM (GMT -7)   
http://www.ncbi.nlm.nih.gov/pubmed/21636218 said...
Abstract
Patients with Gilbert syndrome have an impaired function of the enzyme UGT1A1, responsible for the degradation of 4-OH-estrogens. These elements are produced by the degradation of estrogens and are well-known carcinogens. In theory, patients with Gilbert syndrome accumulate 4-OH-estrogens and, therefore, might have a higher risk for breast cancer, especially when exposed to higher levels of estrogens. If this theory is true, a new risk group for breast cancer would be described, producing new insights in breast carcinogenesis.

[url]http://www.ncbi.nlm.nih.gov/pubmed/21636218[url]




it seems gilbert syndrome can be worse than i thought

sad
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