Are Metametrix Tests Valid? Are the Treatment Suggestions Useful?

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New Member

Date Joined Jan 2012
Total Posts : 3
   Posted 7/22/2012 10:10 PM (GMT -6)   

As the title of this post says, I am asking if the tests that Metametrix uses are valid, and if the company is legitimate. I'm also wondering if anyone's health has improved from taking the supplements that these tests suggest might help.

I'm writing for my 19-year old daughter who was diagnosed with CFS, FM and orthostatic intolerance one year ago. Her stomach has also never felt quite right after a prolonged viral illness when she was in 6th grade. Now, her stomach issues are worse though.

After seeing many conventional docs for a variety of issues, a coworker recommended I take my daughter to a naturopath. My coworker's sister sees this naturopath and was personally helped based on the results of Metametrix tests. I had a phone conversation with the naturopath and she seemed legitimate. But, I read some reviews about Metametrix online, such as this one.

The above posting is primarily concerned with another company, Doctor's Data, but Metametrix is mentioned as well.

In all fairness, I've seen that posts such as the one above tend to discredit all of naturopathy too, in addition to companies that perform biochemical tests. So, I'm a little suspicious of those postings too. But, before taking my daughter to another facility, have her do another blood test, and try another supplement, I'd like to know if 1) the the tests measure valid parameters and 2) if patients have felt any improvement from taking nutritional supplements that these tests suggest.

The Metametrix tests for nutrional deficiencies, as well as mitochondrial dysfunction, seem in line with what Dr. Sarah Myhill recommends in her eBook. Assuming her testing/treatment suggestions are valid, I would want to make sure that the laboratory the naturopath uses is worth it indeed. The tests are certainly expensive, and the last thing I would want to do is give my daughter a treatment that would harm her vs. help her. I'm not expecting conventional medicine docs to love naturopathic medicine or biochemical testing, but I am looking for some unbiased, science-based reviews of the tests.

The additional link below, which specifically mentions Metametrix, makes me cautious as well.

My daughter's doctor said she would be open to "alternative" tests, as long as they were based on scientific studies, and as long as the recommendations they provide are also based on science as well. I realize that not all of the treatment suggestions are going to be "double blind, placebo controlled studies", but I need to rely on more than ancedocal results before proceeding.

However, I have seen several people post test results from Metametrix. And, I also noticed that Rich V has offered his interpretation of several of these results. So, I would be cautiously optimistic that tests such as the ION Profile GI Effects Profile tests might provide some useful information.

Thank you in advance for any advice and experience you can share.


Veteran Member

Date Joined Sep 2011
Total Posts : 1990
   Posted 7/23/2012 7:02 PM (GMT -6)   
Hi Scotty,

I actually just received my test results back from the Complete GI profile test, and I also completed the Adrenal Stress test. The tests were very thorough and my naturopathic doctor recommended them to me.

I haven't done my research on Metametrix Lab Tests, but I will say that their authenticity is a proven fact to me.

I was diagnosed with crohns disease last year, had a colonoscopy and within that colonoscopy did stool testing for all types of bacteria. Everything came back negative. Flash forward to this summer, seeing a new naturopathic doctor, he recommended we find out just what it was that was causing an 'auto-immune' response, and it turns out Yeast/Candida is the culprit!

For whatever reason the immune system was down, allowed for parasites and helicobacter pylori as well, but like I said, the colonoscopy stool samples found this to be negative! So I was shocked when I received these test results back, and now I'm tackling the right issues! :) Hope this helps you.

The tests are quite expensive depending on what you decide to go for, but its not impossible to obtain a receipt and try to have your health insurance company cover the cost later. ;)
Meds: 2400mg Asacol daily
Dietary: Candida-Control Diet, Gluten-Free, VSL#3, Phytostan, ParaGuard, Similase, ADP (anti-fungals)
Amazing Herbs: Slippery Elm, Licorice & Marshmallow Root / Peppermint & Chamomile

Grad student, diagnosed severe Crohns/UC - Sept. 2011
In the past, SCD=remission, Metametrix lab tests reveal yeast overgrowth.

Veteran Member

Date Joined Jul 2007
Total Posts : 715
   Posted 8/25/2012 5:04 PM (GMT -6)   
I have different thoughts on Metametrix testing. I had it done about 3 years ago and it came back with a very postitive gluten intolerance reading. I mean extremely high...I was told I had celiac disease and to go on a gluten free diet.

Well I did for about a month and decided to go to my GI doctor and ask his opinon. He didn't agree with the test at all and did the celiac blood test on me. It came up totally negative but I wasn't myself sure so asked for the intestinal biopsy. He didn't think it was necessary but did it anyway.
I had absolutly no signs of celiac...he said I positively did not have gluten intolerance or celiac.

Nothing else showed up on the Metametrix test.

Veteran Member

Date Joined Sep 2011
Total Posts : 1990
   Posted 8/25/2012 6:41 PM (GMT -6)   
Celiac is not the same as gluten intolerance at all, and gluten intolerance can manifest in the same way as celiac. A few extended family members have celiac disease, and I don't consider my UC/crohns to be similar to those with the actual disease. So by doing the tests, I found candida was out of control and likely causing an auto immune response. Gluten intolerance came up positive on one test and so I follow a strict gluten free diet now.

Whatever your other GI doctor is saying, is wishy washy imo. Unless GI doctors find the common positive result through a standard celiac blood test, they are quick to shut out the likelihood of you having any gluten intolerance at all. Your GI doctor had nothing to do with this test a few years ago if I'm mistaken, and by taking his word over hard evidence, you're avoiding a serious problem that just might be able to fix your symptoms!

Just so you know, standard celiac blood tests only test positive for about 70% of those people with celiac disease, while you and I both tested positive for gluten intolerance on our Metametrix lab tests. These are not ordinary stool tests, and are very thorough. A stool sample tests from inside the gut/immune system to look for positive antigliadin (proteins found in wheat, barley, rye, gluten etc), unlike a celiac test that tests for these inside your blood.

Rest assured, that even going gluten free for a month may not help you notice results, proteins stay in the body longer than we think.
Gluten Free, VSL#3, InflaGuard, Zyflamend, Asacol
Loose Leaf Tea: Slippery Elm, Licorice & Marshmallow Root / Peppermint & Chamomile

Metametrix Labs stool testing reveal yeast overgrowth/parasite
Protocol: Candida Control Diet, Phytostan, ParaGuard, ADP

Post Edited (stereofidelic89) : 8/25/2012 7:26:26 PM (GMT-6)

New Member

Date Joined Aug 2012
Total Posts : 6
   Posted 8/26/2012 5:18 PM (GMT -6)   
I've had the Metametrix ION test done twice.

First time in 2003, it showed I had signs of intestinal bacteria, and a second local test showed I indeed had c. difficile, an intestinal bacteria infection. Then in 2008 it showed that I had a yeast (or candida) infection, and without further testing, the doctor put me on fluconazole - I had what I believe was some bad Herxheimer reaction taking this stuff, but eventually my stools became more normal, sinus headaches, tinnitus, rashes, and paresthesia cleared up. But I never had any second test (either before or after) for that. Both the 2003 and 2008 tests indicated to the doctor that I might be consuming too much alcohol, and that was probably correct. I stopped in 2008.

I was a bit taken aback that the 2008 Metametrix report recommended that I take, among several other things, 4000mg of glycine per day, and I had assumed it was common knowledge that one shouldn't megadose on one amino acid for long because it throws the body's whole processing of proteins out of whack. The doctor didn't think I needed to take the mega-glycine and wouldn't say more...hmm.

So in short, I don't have any definite conclusions about Metametrix, though they do seem to have hit the mark on my GI problems at least twice. It is puzzling that my doctor, both MD and naturopath, has stopped using Metametrix entirely in favor of SpectraCell Laboratories. He's too "cautious" to talk to me about why - maybe it was an insurance problem - my insurance wouldn't pay for the tests, and they are expensive. I have not had any of the SpectraCell tests done yet, so I can't comment on them.

Post Edited (Verseau) : 8/26/2012 5:42:38 PM (GMT-6)

Regular Member

Date Joined Jan 2012
Total Posts : 78
   Posted 8/30/2012 12:49 AM (GMT -6)   
Hi All,
I've had Celiac blood test done and colonoscopy which showed no sign of Celiac.  Still having gastrointestinal trouble and saw a GP/Naturopath and she did a blood test for Celiac gene which I do have.  My son has had gut trouble and  whilst he doesn't have Celiac's - he has the gene.  My sister has Celiac's and she had virtually no symptoms and was diagnosed when she was 38 after miscarrying (apparently it can be a cause of miscarriage).  She went GF and has had a baby and is now pregnant with her 2nd.
From what i've read, I do believe firmly in the relation between CFS and diet/gut trouble.  I went off dairy and sugar and began to feel better within a week.  I was basically off the dairy and sugar and doing really well for over 8mths until I went back on these things and now I feel horribly sick again.  I've also had a number of friends who've been suffering fatigue (not diagnosed CFS) and have gone gluten free and have improved dramatically. 
I guess what i'm trying to say is that I don't need a test to tell me that diet plays a significant part in my CFS. Now I just need the kick up the bum to go back to healthier eating.
All the best to you all and I hope you get better soon xo
Dx Fibromyalgia, CF, Severe TMJ, Osteopenia of lower spine, arthritis of L hip, bursitis of L shoulder and hip, GERD, Perimenopause and query RA. Deleting Dairy and sugar out of my diet was what set me on the road to recovery.

"Behold the turtle who never makes progress unless he sticks his neck out" Unknown

New Member

Date Joined Nov 2010
Total Posts : 5
   Posted 12/6/2012 7:27 PM (GMT -6)   
Hey stereofidelic89, I just wanted to see how you were doing after following up with the candida. Have your symptoms improved? Some say that candida can follow Crohn's disease, just like H. Pylori. I also have Crohn's disease and have taken Metametrix tests before but nothing meaningful came I don't know! Good luck! Nikki

James Aiden
New Member

Date Joined Dec 2015
Total Posts : 2
   Posted 12/28/2015 5:04 AM (GMT -6)   
Hey stereofidelic89,I guess what i'm trying to say is that I don't need a test to tell me that diet plays a significant part in my CFS. Now I just need the kick up the bum to go back to healthier eating.
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