I have been taking LDN for several years now for CFS. Initially, it took almost all my symptoms away with only an occasional flare-up if I over-exerted. It boosts your endorphin levels which helps not only with pain relief, but endorphins also help to regulate your immune response. For some reason, after a few years, it has stopped working for me. I am now investigating what could be causing it. One forum suggests that yeast overgrowth can interfere with its efficacy. BUT I highly recommend trying it. It has virtually no side effects, it is inexpensive, and it can be taken with other medications as long as they are not opiates. There's really nothing to lose, and so much to gain. I got my life back for a few years anyway.