Saw Dr. Jacobson from 1999 until he retired. Treated for CFS with Sinequan (which now only offered in generic form called Doxepin). I can never get completely off it. Remain on the lowest dose of 10mg. Have tried many times but symptoms or even new mysterious symptoms appear. Then need to go to a higher dose until symptoms are gone. Be aware, symptoms will manifest themselves into something completely different. Just increase the dose until they're gone. Then slowly drop back dose. It will work for you AGAIN if you start slow at 10mg then increase to 20mg, then 30mg, 35mg, 50mg. Or continue higher up measurably to 100mg. Once symptoms are gone, back down slowly the same way until 10mg. I've been on it for 17 years. Probably can never get off it.