Normal C4a, High TGF-Beta1

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New Member

Date Joined Jul 2015
Total Posts : 1
   Posted 7/5/2015 8:43 AM (GMT -6)   
Hi all,

I'm working with a doctor to try and find out underlying cause for my symptoms (fatigue, chronic pain in hands/lower arms and feet, brain fog, etc.)

The first pass of blood tests showed normal C4a (263), but very high TGF-beta1 (9700). I also showed evidence of EBV reactivation (early antigen 120), so she is focusing on treating the EBV with antibiotics for now.

What concerns me is the TGF-beta1. She said she only sees that with either "chemical sensitivity or mold exposure" and asked if either of those sounded like they could apply. I didn't really have an answer, so she moved on and started discussing treatment for the EBV.

She said a couple of my test results she sees in Lyme, but that because don't have any risk factors (city-dweller, not even close to being outdoorsy---much less a camper and never recall a tick bite in my life) she didn't think that could be it.


I see a lot about elevated TGF-beta1 in discussions about Lyme and mold exposure, but it's usually along side elevated C4a. Anyone know what would cause elevated TGF-beta1 but NOT elevated C4a? Could my reactivated EBV be the cause of the elevated TGF-beta1?

Anyone else have elevated TGIF-beta1, but low C4a and maybe know what caused it in their particular situation?

It seems to be difficult to pinpoint TGF-beta1 based on what I am reading (it appears to occur in many situations!), but hoping my situation sounds familiar to someone out there.

New Member

Date Joined Jan 2016
Total Posts : 3
   Posted 1/2/2017 5:29 PM (GMT -6)   
I was excited to find your post and then sad to see no one replied! My TGF is 22,000 with a normal C4a. Most other mold labs are within range. I dont think mold is an issue for me but I can't find a good explanation to why the TGF is so incredibly high

New Member

Date Joined Jan 2017
Total Posts : 3
   Posted 1/4/2017 6:11 PM (GMT -6)   
holy crap 22,000! Mine is at 8500. What are your other symptoms?

Veteran Member

Date Joined Sep 2015
Total Posts : 2596
   Posted 1/17/2017 9:36 AM (GMT -6)   
Maybe try testing some of the other mold indicators: msh, vip, vegf, c3a, etc. You can find a list on If your c3a would be high it sometimes indicates Lyme. Have you had lyme testing through a lab like IGeneX?

Also, I think c4a is a tricky test. Mold guru, Shoemaker, prefers it is done through Quest (I think). Below is an excerpt from surving mold explaining TGF beta test:

TGF Beta-1 is a protein that has important regulatory effects throughout innate immune pathways. This protein helps control the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement (motility), and the self-destruction of cells (apoptosis). The TGF Beta-1 protein is found throughout the body and plays a role in development before birth, the formation of blood vessels, the regulation of muscle tissue and body fat development, wound healing, and immune system function (especially regulatory T-cells).

TGF Beta-1 can impair T-regulatory cell function, which in turn contributes to the activation of autoimmunity, yet TGF Beta-1 also plays a role in suppressing autoimmunity(!). TGF Beta-1 has become important in the exploding incidences of childhood asthma, raising the tantalizing issue of remodeling due to biotoxin exposure. The EPA says that 21% of all new cases of asthma are due to exposure to Water Damaged Buildings. If an individual develops wheezing after exposure to a water damaged building, look for remodeling to be the cause. Remodeling means "something" happens that the airway changes to be more reactive and in need of medications to reduce wheezing. Neurologic, autoimmune and many other systemic problems also are found with high TGF Beta-1.
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