weird hydrocodone effect

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Veteran Member

Date Joined Jun 2005
Total Posts : 610
   Posted 1/2/2008 10:56 PM (GMT -6)   
Hello everyone, and happy new years. I wanted to share my 'NEW' experience with hydrocodone. First of all I wanted to say I'm on kadian and in the process of being tapered off by my doctor. Well, I've used hydrocodone hundred's of times over the past 6 years, but I havent taken it for awhile. Well I got a bottle of it about a week ago and took them to help with breakthrough pain and got very very very sick on them. It's like my body decided it's allergic to it now. about a week ago I took 2 5mg around 8:30 pm and fell asleep about 20 minutes later, then woke up around 9:30pm with very severe nausea and vomited about 5 minutes later and kept on vomiting like crazy every 10 minutes. at around 2am I couldnt take it anymore, I had nothing in my stomach to throw up but kept on anyways so my stomach started to hurt very bad and went to the ER. first the gave me zofran thru an IV with fluids, then when that didnt work they gave me phenergan with diladid and it still didnt stop the nausea, actually I didnt stop throwing up til 9am that morning, that's 12 hours of vomiting up non-stop!!! I didnt even know it was possible to throw up that much. Well I didnt know if was the hydro and took another dose that night with food and got this very weird taste in my mouth and still got nausea. Is it normal for my body to decide it doesnt like this med anymore? It's not like Im not use to narcotics or anything, I am very tolerent, but I'm so confused on why it made me so horribly sick?? I told my doctor this morning and she just shrugged it off. I'm gonna call around tomorrow for a new doctor but til then I dont know what to do. I'm in pain but vomiting is way worse to me, and the taste in my mouth is like I was sucking on the hydrocodone instead of swollowing it (which I wasnt sucking on it). Does anybody know if this is a normal side effect at all or anything?? I know the nausea and vomiting can be but that nasty taste in my mouth and the anxiety is driving me crazy!!
thanks again

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Date Joined Jan 2005
Total Posts : 9152
   Posted 1/2/2008 11:28 PM (GMT -6)   
Hi kitty...

Sorry about your awful experience. It might have just been some sort of intestinal 'bug' you had and not the hydro at all. When you get sick your body eliminates anything in the stomach so it can fight the 'bug'...and maybe it just happened after you took your medication.

Just a thought...
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Fibromyalgia, Ulcerative Colitis, Insulin dependent diabetic, collapsed disk, dermatitis herpetiformus, osteo arthritis in spine and other locations.

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Regular Member

Date Joined Mar 2006
Total Posts : 61
   Posted 1/3/2008 6:53 PM (GMT -6)   



Hello Kitty:

I just thought I would chime in with a similiar type experience but different med I take Percocet and have been taking this med since 1995 with no side effects and good results upon changing pharmacies about 2 months ago I have been taking the percocet and have been having really severe stomach pain after systematically eliminating foods and other possible causes I found I was getting this stomach pain after taking this percocet about one and a half hours after taking it every time I asked the Pharmacist and my doctor who said this is not a side effect of this med and I know that after taking it for years but I remain convinced this med is the cause and I do not have stomach pain when I don't take it it seems healthcare professionals think if a med comes directly from a Pharmacy then NOTHING can be wrong with it myself I do not believe this as these meds are in great demand here in Canada by people who abuse it and sell it.

Anyway this is my continuing experience with a med I have taken for years with no side effects until recently with a particular pharmacy I hope you can resolve it and it dose not happen again it could be you were just sick as Chutz said that is what my Doctor said to me but I continue to have stomach pain when I take it

Take Care


Regular Member

Date Joined Dec 2005
Total Posts : 256
   Posted 1/3/2008 8:53 PM (GMT -6)   
It may have nothing at all to do with the Hydrocodone itself.

One thing few docs acknowledge (and almost as few even realize) is that virtually no two pain medication formulations by two different manufacturers are really the same. They may have within 5% the identical amount of active ingredient, but in order to get around other companies' patents and such, most generics in particular are formulated with less than ideal chemistry.

Mallinkart generic "lortabs" (5/ or 10/500 generally) were some of the worst in this regard for me. It just seemed like the pills were formulated with something that my body didn't like at all. A disgusting taste was definitely part of this.

I think that your vomiting incident, while it *COULD* have been at least partly opiate-related......was more likely a matter of bad timing, something in your stomach that wouldn't have ordinarily been any problem but which "triggered" the vomiting reflex once you were exposed to something else (the opiates and/or pill formulations). Tracking down a single, clear cause of vomiting incidents can be darn tricky, as I have learned over the past two years as my condition has progressed to include chronic nausea & vomiting -- which has recently, blessedly been brought under control with Marinol and Medicinal Marijuana (but that's a long story for a thread more specific to the wonders of Cannabinoids).

I would say that you should be very cautious about taking more tablets by this manufacturer, particular if it isn't a company whose formulation you've taken before. It may, as I said before, not really be about the Hydrocodone itself at all, though that is definitely still a possibility.

I would suggest making sure that you have an ample supply of Promethazine suppositories for the future, just in case you ever have such an incident again; even though you are tapering off of opiates, IMHO it is always wise to have a potent anti-emetic available in a suppository form.

It's odd that you didn't respond to Zofran; that's an extremely powerful anti-emetic. Combined with Promethazine, virtually any "normal" source of vomiting should be completely resolved. I have to believe that there were other factors at work, complicating the obvious ones like the hydrocodone itself and/or pill formulation. Maybe something you ate?!
Conditions: Chronic Pelvic Pain, Severe Lesioning of the Spermatic Cord, Reiter Syndrome (Reactive Arthritis and Myalgias along with a slew of other symptoms), Sacroiliitis, Costochondritis, widespread Tendonitis, and on and on. Typical daily pain levels exceed 8.5.

Medications: Methadone, Oxycodone ER, Dilaudid, Lidoderm (lidocaine) Patches, Flexeril, Soma; many herbs & supplements.

Previous medications: Oxycontin, Opana ER (12 hour time releasd Oxymorphone, Endo Pharm.), generic Mylan Fentanyl patches (two 100mcg/hr patches worn simultaneously, changed every two days), Kadian, Avinza, MS Contin, Lortab (hydrocodone), OxyIR, Cymbalta, Lyrica, Neurontin, Amitryptyline, every NSAID known to man, Prednisone, and many more.

Regular Member

Date Joined Jan 2008
Total Posts : 20
   Posted 1/4/2008 9:39 AM (GMT -6)   
Hi Kitty...after being off meds for 2.5 months, I took a 5/325 perc and a short time later, a 10/325 Lortab. I had the same experience as you but I thought I was oding due to my body not being comfortable with the dosage. My two cents...


Veteran Member

Date Joined Jun 2005
Total Posts : 610
   Posted 1/7/2008 2:49 AM (GMT -6)   
Thanks for the Replies. I decided to not taper off the methadone right now and threw away the bottle of hydrocodone. It was the watson brand. I tried taking half a dose and still got that nausea (w/no vomiting) and that horrible taste in my mouth. I really think It has something to do with all my stomach problems. I had gallstones at 14 (im 24 now)and gallbladder removed when I was 15, then very shortly after when I kept still having the same pains as gallstones they found out I had pancreatitas which was due to a deformality of my pancreas. I have had so many problems with my stomach that I had a GI doctor tell me when I was 17 years old that I had 9 things wrong with my digestive system. Well that doctor is gone and I went to a new GI doctor that was 3 hours away from where I lived that did a colonoscopy(year and half ago) with no drugs to calm or sedate me. I was so traumatized by this that I refuse to ever have a procedure or any surgeries done to me again, I dont care if I'm dying, I now have a big phobia of them. They said they couldnt give me meds cause I was taking the fentanyl patch at the time and they said they didnt need to give me any other meds. So I dont know what to do about my nausea and vomiting, it gets so bad that it throws me into a severe depression. It took me 3 months to get over the colonoscopy, I had vomiting and a horrible migraines. And I know your thinking I should of sued them or something but I thought that was normal til a few months ago when I started overhearing other people talking about their's and they all said they didnt feel a thing, I laid there screaming and crying and holding on the side of the hospital bed while the doctor was doing it, and he didnt care. Well now I dont know what to take for a BT med. I just think its so strange that I could have gotten sick from a med I've taken a thousand times before with no side effects, and suddenly it's like my body decided to change it's mind now what I can and canot take and I have no doctor to even tell me if there is still something wrong with my stomach like my pancreas acting up again, I guess I'll never know what caused that horrible night. Well anyways, thanks for listening!!!
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