Why some people get side-effects....

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Lakeside
Regular Member


Date Joined Jun 2007
Total Posts : 138
 		   Posted 4/25/2008 12:01 PM (GMT -6)   
Hi Everyone!
 
Yesterday, I remember a post about why some of us get bad side-effects to meds & others of us don't, etc.  I posted that I read somewhere that now they think there is a genetic basis for these reactions:  you're either a PM, or poor metabolizer or a Um, an ultra metabolizer...but I couldn't locate the article.
 
Chutz, if this is premissible, there is a good link from the Mayo Clinic site to this explanation.  If you go to the Mayo Clinic website @ www.mayoclinic.com and type "personalized medicine" in the upper-right hand search box, you'll get a search result (it's the 1st choice on the list) entitled "Personalized Medicine: Tailoring Treatment to Your Genetic Profile.
 
I found it fascinating!  I get sick from almost everything (I can't even take some OTC's!) yet other people I know can take just about whatever they're RX'd...
 
Interesting reading on a rainy, dreary day like this.
 
Hope this OK to post---I'm not reccm'ding anything---just an interesting article on why some of us are "reduced" to Advil for everything!
 
Thank you!
 
~Lakeside -- inside, as it's foggy & raining & yucky today!
Nov. 06-- Lammy @ L4, removal of spinal cystic tumor @ L4/5(benign)
Dec. 06--Re-operation for post-surgical spinal fluid leak.  2nd surgery caused sciatic nerve damage & radiculopathy in R leg/foot,  increased spinal instability (grade 1 spondy, 17%), epidural scar tissue binding nerve roots, damaged facet joints & worsened DDD @ L4/5
Jan.  08--PLIF fusion/discetomy surgery w/pedicle screw instrumentation @ L4/L5, another lammy (@ L/5 this time) & bone marrow harvest from left iliac crest for packing bone around disc cages after total discectomy @ L4/5. Good relief from sciatica & leg/nerve pain, tho some residual CP--hope to be "Healing Well"...

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Chutz
Forum Moderator


Date Joined Jan 2005
Total Posts : 9145
 		   Posted 4/25/2008 1:06 PM (GMT -6)   
Hi,

Helpful articles and information are always welcome! Thanks for taking the time to post the link.

CHutzie
Co-Mod Fibromyalgia & Chronic Pain Forums
~~~
Fibromyalgia, Ulcerative Colitis, Insulin dependent diabetic, collapsed disk, dermatitis herpetiformus, osteo arthritis in spine and other locations.
***************

The only difference between genius and stupidity is that genius has it's limits. Albert Einstein: (1879-1955)

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sjkly
Veteran Member


Date Joined Dec 2007
Total Posts : 2113
 		   Posted 4/25/2008 4:47 PM (GMT -6)   
Why some of us have side effects. Double omision of the gene responsible for plasma psuedocholenestrase.
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Lakeside
Regular Member


Date Joined Jun 2007
Total Posts : 138
 		   Posted 4/25/2008 5:10 PM (GMT -6)   
Yes!!!

Some people (poor metabolizers) can't break down certain drugs & get side-effects and/or drugs stay in their system too long; other people (ultra metabolizers) break down drugs too quickly and a regular dose is not effective and/or they may need more doses to even get the basic effect! In these people, a toxicity can happen also. b/c they need so much for effective relief.

Some drugs, like penicillin, don't need to be "broken down" and most people can take them (unless physically allergic) but other drugs, like tamoxifen, say, must be broken-down by enzymes to be effective, and those w.o the gene (or have the double omission) get some or all of the nasty side-effects & not much benefit either.

I was dumb-struck! I think this is an amazing study. I hope in the future doctors would be able to "type" a person b4 RX'ing anything to spare us the discomforts of negative side-effects w/o having to endure them. Have our meds tailor-made, so to speak.

~Lake
Nov. 06-- Lammy @ L4, removal of spinal cystic tumor @ L4/5(benign)
Dec. 06--Re-operation for post-surgical spinal fluid leak.  2nd surgery caused sciatic nerve damage & radiculopathy in R leg/foot,  increased spinal instability (grade 1 spondy, 17%), epidural scar tissue binding nerve roots, damaged facet joints & worsened DDD @ L4/5
Jan.  08--PLIF fusion/discetomy surgery w/pedicle screw instrumentation @ L4/L5, another lammy (@ L/5 this time) & bone marrow harvest from left iliac crest for packing bone around disc cages after total discectomy @ L4/5. Good relief from sciatica & leg/nerve pain, tho some residual CP--hope to be "Healing Well"...

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