Oxycotin...Why Doesn't it work for Me ?

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

Regular Member

Date Joined Oct 2009
Total Posts : 175
   Posted 10/23/2009 7:35 PM (GMT -7)   
 I'm new to the site and was just wondering if anyone else has had the same experineces as I've had with oxycotin. I take Supeudole which is oxycodone in a rapid release pill rather than the slow release of oxycotin.  The problem is that although they are the same drug, the rapid release oycodone works very well for me but the same amount of mgs in oxycotin doesn't have near the same effect. I would say that oxycotin only works about 50-60% as well as the rapid release. So I fortunate that my pain doc allows me to take the rapid release as my main painkiller and only take the oxycotin at night.  Generally docs want you to take oxycotin as the main painkiller and use the rapid release oxycodone just for break through pain. That just doesn't work for me.  Just wondering if anyone else has the same problem.   Thanks for reading.....Stringray

New Member

Date Joined Oct 2009
Total Posts : 2
   Posted 10/24/2009 8:09 AM (GMT -7)   
Hi stingray,

I believe the reason you are experienceing this issue, is that the same amount of Oxycodone (10 mg for axample) in a timed release form is being delivered over an 8-12 hour period, vs. immediately and all at once in a quick release formulation like Supeudole. Another way to say this: 10 MG of Supeudole infuses your system all at once. 10 MG of Oxycontin infuses your system over an 8-12 hour period making it much less effective in relievng your pain. To get the pain relief you are looking for, I believe your doc needs to give you a higher dose of Oxycontin, and NOT the same #'s of mg's of the rapid release Supeudole. I am not a doctor, but this is just my opinion from personal experience and research. Best of luck to you.

Regular Member

Date Joined Oct 2009
Total Posts : 175
   Posted 10/24/2009 10:21 AM (GMT -7)   
Thanks for your reply. I'm not sure that's how it's supposed to work but your theory certainly matches my problem. I figured that maybe it is an absorption problem where my body just doesn't absorb the Oxycontin very well. Was just wondering if anyone else has encountered this problem. Thanks again for the reply. Take care

Veteran Member

Date Joined Nov 2007
Total Posts : 6795
   Posted 10/24/2009 11:57 AM (GMT -7)   
Welcome to the Chronic Pain forum of Healing Well. We aren't doctors here and aren't here to give medical advice, but this is the best support group on the internet, IMHO.

We can share experiences, but remember we all react differently to medications, so the best thing is always to discuss this with your doctor. Your pharmacist can also be a great source of information. That being said, there are differences between IR (instant release) medications like oxycodone, and ER (extended release) medications such as oxycontin. Usually, an ER medication can help our body maintain a more continuous level of a medication (hence the portion of the name "contin" for continuous), and that helps prevent breakthrough pain. Although it is possible to also need a medication to help with BT pain. I think you need to give your doctor the feedback about how the oxytcontin is/isn't working.

You mention aborption issues, and each of us has our own unique issues with our body (let alone other medical problems), plus perhaps taking the oxycontin at night is affecting your experience with the IR medication. I'm not a doctor so just talk with your doctor and see about possibly making some adjustments.

Unfortunately, we rarely get 100% pain relief, even with a good medication regimen. But you can work with your doctor to get it as close as possible.

Again, welcome!

And Welocme to you also, HadEnoughPain.


Regular Member

Date Joined Jul 2008
Total Posts : 243
   Posted 10/24/2009 12:48 PM (GMT -7)   
Apologies in advance if the math in this post causes anyone's head to explode.. tongue

The general conversion information for Oxycontin is on page 22 of the package insert. Obviously your doctor has to make the final decision on dosing based on your clinical presentation and other health issues, but that information is made available to give a general idea of where one might start when converting.


package insert said...
When converting from oxycodone, divide the 24-hour oxycodone dose in half to obtain the twice a day (q12h) dose of OxyContin.

So, if you want to calculate from immediate release oxycodone to Oxycontin, you have to start by adding up the total amount of oxycodone you take in a day. Then you take that total amount and divide it by 2, which will give you the Oxycontin dosage you'd take every 12 hours. For example, if you're taking oxycodone 10mg immediate release tablets 4 times a day, that means you're taking 40mg of oxycodone over 24 hours. You divide that by 2 and that gives you a dose of 20mg of Oxycontin every 12 hours.

If you were to do that math backwards, Oxycontin 10mg tablets would give you 20mgs of oxycodone in 24 hours, which would be the equivalent of taking 5mg of oxycodone immediate release 4 times per day. So, if the oxycodone content of your Supeudole dose is greater than 5mg every 6 hours/20mg per 24 hours, it would explain why the 10mg Oxycontin dose doesn't work well for you. :-)
The difference between perseverance and obstinacy is that one comes from a strong will, and the other from a strong won't. ~Henry Ward Beecher

Regular Member

Date Joined Oct 2009
Total Posts : 175
   Posted 10/24/2009 4:24 PM (GMT -7)   
Thank you everyone for your replies. I have tried different variations of oxycodone rapid release and Oxycontin. I presently have a good routine worked out with taking oxycodone rapid release during the day and Oxycontin at night. I was just wondering about other peoples experiences with this medication. Thanks again to everyone for your replies. I think it is so helpful to have a site like this if for no other reason than to know your not alone in your battle with pain and other health issues and also to learn from others peoples experience is just great. Thank you again for all your responses.


New Member

Date Joined Oct 2009
Total Posts : 1
   Posted 10/30/2009 1:03 AM (GMT -7)   
I can relate to you stingray - the immediate release seems to work much better for me as well, but perhaps it's the type of pain? I just hate the itches I get from it - right now my eyelids are itchy, but it's worth it to take the edge off the pain.

To introduce myself (just joined / first post). I have a complex fistula which I've had since January. 6 operations later I'm back at square one with another massive infection and 4 hourly painkillers consisting of Endone and Panadeine Forte as I've run out of the slow release stuff - which don't take the pain away but make it a little more bearable.

What's the next step after Oxycontin and Oxycodone? Is there anything else or just higher milligrams? I'm finding that I'm building up a tolerance to them and they aren't as effective as they used to be and I'm worried that soon they won't work at all.

The doctors took me off antibiotics on Monday to see if I'd get infected again and today it's so bad that I can't sit or even walk.

Is this the right place to talk about this? Sorry if I'm rambling on in the wrong place!

Regular Member

Date Joined Oct 2009
Total Posts : 175
   Posted 10/30/2009 7:09 AM (GMT -7)   
Hi Wifey 11
I just joined recently myself and have found this site very helpful and the people I've chatted with are just super nice. You mentioned being itchy and I'm glad to hear that someone else has this problem. (well you know mean...lol) I get mildly itchy all over too. I find that by taking just half and allergy pill that most times that helps alot. Keep in mind that you should never try anything new without consulting your doctor first .I have tried alot of different pain meds but always end up back at oxycodone  in both slow release and rapid release.  My dose has significantly increased over the years but have little choice but to continue. At least until I find a better solution. I don't know what the next step would be after oxycodone or even if there is one. I know people who are using morphine and having good results. I think the most important thing is to find a good pain specialist. That sometimes is no easy feat. I just started seeing a new pain doc and he has been really good. In my opinion to many docs just throw everyone into 1 category and of course everyone reacts differently. So the best advice I can give you is to find a really good pain specialist and a good pharmacy that will let you know if new things come on the market. Sometime a good pharmacist can also be of great assistance. Hang in there and welcome to the site. Maybe we can chat sometime in the chat room. Good luck and thanks for the reply.

Post Edited (stingray) : 10/30/2009 8:24:06 AM (GMT-6)

New Topic Post Reply Printable Version
Forum Information
Currently it is Saturday, November 25, 2017 2:28 AM (GMT -7)
There are a total of 2,897,754 posts in 318,046 threads.
View Active Threads

Who's Online
This forum has 157603 registered members. Please welcome our newest member, musquraq.
223 Guest(s), 3 Registered Member(s) are currently online.  Details
George_, Lallie, randynoguts

About Us | Advertise | Donate
Newsletter | Privacy Policy & Disclaimer
Follow HealingWell.com on Facebook Follow HealingWell.com on Twitter Follow HealingWell.com on Pinterest
©1996-2017 HealingWell.com LLC  All Rights Reserved.