Question regarding different brands of medication

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Regular Member

Date Joined Mar 2007
Total Posts : 167
   Posted 2/4/2010 11:46 PM (GMT -6)   
Hey all!  I hope you all are doing great.  I have a question regarding my b/t medication.  I am on oxycodone ir 5mg and am directed to take 2 every 8hrs as needed.  I have been getting them filled and they are ok at relieving the b/t pain.  I keep telling my pm doc that they are not helping as they used to but the pm just keeps wrighting for the same dose and frequency.  Oh well, anyway, my question is everytime I got my presription filled I got these little capsules.  I would take 2 when I noticed my pain flaring up (mostly at work as I am on my feet all day).  It would take the edge off.  I got my prescription filled this last time and noticed the pills were a different color.  I looked them up on the net and quess what?  They were the 15mg.  So instead of me being instructed to take the 5mg 2x8hrs I was told to take 15mg 2x8hrs.  I called the pharmacy and they caught the mistake and said BRING THEM BACK so I did.  They thanked me and I got the right meds and went on my way.  I got home and opened the bottle and still noticed they were different than the 5mg capsules I usually get.  I looked them up on the net and it said they were in fact 5mg oxycodone but a different manufacturer.  I took my first dose at work when my pain flared up and almost nothing happened.  It helped a little bit but not at all what the capsules did.  I swore there was a mistake so I again researced on the internet but everything said they were what they were supposed to be.  I continue to take them as I need them but they do not help.  Can someone tell me why this is?  Why are these not working when the others did?  THey are both supposed to be the same exact medication.  I need some help here.  Should I discuss this with my doctor or just leave it alone?  Am I going crazy or has my tolerance or pain levels gone up that fast?  Any feedback would be greatly appreciated.  Again, I hope you all are doing well.

Veteran Member

Date Joined Mar 2008
Total Posts : 3089
   Posted 2/5/2010 12:19 AM (GMT -6)   
Hi Shaw,

Different companies make generics of the same medicines. For generic medications there is some leeway. In other words, the generic medication produced may have slightly more or slightly less of the active ingredient in it (so you may be taking something like 5.5 mg or 4.5 mg, depending on the batch & the company) than does the brand name medicine (which is highly regulated & will have exactly 5 mg). Also, different generics contain different inactive ingredients. The combination of the difference in inactive ingredients & the difference in actual oxycodone present in the two different generics probably accounts for your different response to the same medication.

Perhaps you can explain the problem to your pharmacist & ask to be given pills from the manufacturer who's pills work better for you (if they have them in stock, the brands they carry may vary from time to time due to price, availability, etc). Or you could ask your doctor to write a prescription requiring you to get the brand name medication (although this is more expensive & may not be covered by your insurance since there is a generic form available). Like you said, another possibility is tolerance, but due to the sudden nature & the correspondence with the new meds, I'd be more suspicious of the medication itself.

I hope this all makes sense, it's pretty late & my eyes (and brain) aren't working so well.


Post Edited (skeye) : 2/4/2010 10:24:46 PM (GMT-7)

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