I take Amitriptyline. It is a medicine that has to be slowly increased over time. To get to my first stage of dosing took a little over a month. To get to my most recent dosage increase took 2 weeks. Needless to say I am on a rather high dose. I have taken it for 2 years now. It is a very usefull medicine, if you can handle the side effects, and if you are patient with the slow increases. It unfortunatly causes "discontinuation syndrome", so that is something to think about. Lapses in dosing, going with this medicine esp at higher dosing, is a no no. Also, it has adverse interactions with many many other pain medicines and you will need additional (more frequent) monitoring. Here is useful information~~>
~~>"The TCAs show efficacy in the clinical treatment of a number of different types of chronic pain, notably neuralgia or neuropathic pain and fibromyalgia. The precise mechanism of action in explanation of their analgesic efficacy is unclear, but it is thought that they indirectly modulate the opioid system in the brain downstream via serotonergic and noradrenergic neuromodulation, among other properties."