Yes I have currently been on that medication going on 4 months. For me it has worked well until very recently. For the previous 3 months, my pain was at the moderate to moderate severe level and it DEFINATELY works better than vicodin, and is significantly stronger than tramadol. Its considered to equipotent to oxycodone's lower end of the pain relief scale, as it has relatively low side effects at lower doses (50, 75, 100), but moderately heavy side effects at 150-200. Reportedly, side effects aren't well tolerated beyond 200 mgs so there is a ceiling of use. It is similiar to tramadol, but its key differences are that it has stronger MOR receptor activation (opoid activity), stronger NE reuptake activity, but almost no SE reuptake activity (compared to tramadol). Its a single molecule thats active, so it doesnt have to be processed by the liver first to become active like tramadol and codeine do. It has less drug interaction and generally less side effects, but it does have a strong anti-depressant like effect. Medication can cause a stimulant like effect that turns into a more sedative like effect, but in general these side effects are managable.
The medication worked for 3 months with very little tolerance building for me. Whenever my pain was a 6 to 7, it did well to bring it down. Once my pain hit an 8 though, it just wasn't enough alone (though it still usually helped) and celebrex or ibu had to be used to help bring the pain down more. To me this medication is very useful because unlike percocet, it seems to build tolerance slower. However, percocet seems to take effect quicker. I personally believe the medication is slightly stronger than percocet overall in dose per dose comparison, and it seems to last slightly longer for pain relief. However, as I stated, its limited to treating moderately severe pain in my case and over the past several days ive been in the 8-9 pain scale region a few times, so its become less useful. I have an appointment with my PM doctor today, so we will see what he recommends, since this medication did work well for the most part.
PS- If your doctor recommends a trial of it, atleast try it out. Its lower risk of dependency coupled with its NE properties make it suitable for nerve pain (IMO)
MRI revealed a bulging disc w/gel lost at L5 and showed the bulge touching nerves, causing sciatica. Diagnosed w/ Arthritis which is responsible for joint inflamation pain. Treatment: Nucynta 50-100 mgs every 6 hours (schedule II narcotic, moderate MOR receptor activity and moderately strong NE reuptake inhibition), Celebrex 100 mgs, Epidurals, Radio Freq nuerotomy (sept 8th, 2010)