If it were my choice I would say Humira. I was on Remicade for three and a half years. I went every 4 weeks for the infusions. I had horrible veins to begin with and had to have a Port A Cath put in chest which made my life a lot easier. Remicade helped me initially and then after a while it stopped being so effective. At the loading doses they said we would do the infusions every 8 weeks but I never could go 8 weeks in between the infusions. By week 5 I was sick as a dog, so we did them every 4 weeks. It really is a drug that should be tailored to your needs. They did not realize back then either that Remicade does not stay in your system as long as they thought it did. Not everyone can take Remicade either, you run the risk of having reactions from mild to severe. I had a bad reaction on my 3rd infusion and had to be given pre-meds from then on. You can also build up antibodies to the drug which I did and I also have drug induced Lupus because of Remicade. After my infusion was finished and I spent nearly a full day at the hospital for each one, I had to come home and go to bed and stayed there for the next three days because I always felt like I had the flu. By day 4 I was better and then it repeated itself in 4 weeks. Don't get me wrong, I am not knocking Remicade because it did help me but I went thru alot to feel better for a short time. I cannot tolerate steroids I go into congestive heart failure on them so Remicade was my saving grace at the time. I have seen and heard of a lot of different types of reactions to Remicade and they have been pretty nasty but I have not heard anything like that with Humira. It is the mouse protein in the Remicade that makes everyone so sick.
After the Lupus dx my gi switched me over to Humira and let me tell you there is no comparison. I feel so much better on Humira. I would much rather give myself a shot in the leg every 2 weeks than go hook up to an IV for several hours, then be sick for 3 days. My gi was a big Remicade fan because it helped so many of us, but once he started seeing our response to Humira he switched us all over. There are no pre-meds to mess with either. I don't get sick after my shot none of that. You can get Humira in Pens or a regular syringe, I prefer the Pens, I am terrified of needles, lol. I am on medication for Lupus and as long as I am on a TNF blocker the Lupus will remain. Of course convenience is another reason I love the Humira.
I have been on steroids long term before I started having the CHF started and I do know what you mean about the mood swings and the headaches. I had a horrible time sleeping when on them. Because of my long term use I now have osteoporosis from that evil drug. Prednisone is a real love hate relationshipo drug. We love how it can make us feel better but hate how it makes us feel, being a crohnnie you understand what I am saying about it, lol.
As with all medication there are possible side effects. When you read about the side effects from the biologics it scares you to death. But, please keep in mind none of this may happen to you either. If one person reports a problem then by law they have to list that side effect. That is on any drug. The 3 1/2 years I was on Remicade my husband was very upset with me, he was so afraid of me either dying or getting cancer. Its like I told him, yes, and I may walk out the door in hour and get ran over by a car. I had to have some quality life and Remicade gave me that and there was no other drug available to try me on. Humira has pretty much the same possible side effects but again, I need the quality life. The one thing I do is in the winter months is avoid crowds because of the immune system being lowered. So, far knock on wood this has worked for me. If anything the TNF's has made me take better care of myself to keep from getting sick with something else.
If you have any questions on these drugs let me know. By the way, both companies offer help with your co-pays. I pay $5 for my Humira and this stuff costs thousands of dollars. Take care. Susie