Hi, the reason methadone gives such a sustained relief is that is has a very long half life, I believe upt to 72 hours. So , even though it wears off over time, like all others, it is at the three day period, when you will notice it the most. Not being able to titrate down on it, while going up on the replacement med is a big hardship . I was on 30 mg daily, and my new dr. took me down 10 mg the first month, and put me on 20 mg oxycontin BID, I was having mini withdrawals constantly, the next month I went down to 15 mg methadone, and 30 mg of oxycontin two times a day. STILL had symptoms of withdrawals, could not sleep, night sweats, increased pain, weird spasms. So the third month went to 10 mg of oxycontin, stayed on 30 mg oxycontin bid, but added breakthrough vidodin up to 6 times a day. Then down to 5, and thiry still two times a day. Then to 2.5 mg of methadone, and then to 2.5 every other night. It took months, and I was still having the symptoms, after 6 or so months I was on Oxycontin 40 mg every 8 hours, because I actually get withdrawals if I try every 12 hours. AND I take breakthrough meds every four hours. I miss the methadone, and think I will try the fentanyl patch again, if dr agrees. It is the closest to methadone in longacting, no ups and downs. Morphine does nothing for me, and oxycontin is not that great for me. I wish you luck trying to find what works best for you.