Pain meds and Anxiety

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Regular Member

Date Joined Mar 2007
Total Posts : 166
   Posted 11/3/2010 7:17 AM (GMT -6)   
Hello all!  I am now on morphine cr and oxycodone for b/t for pain management.  My question is this.  I was on oxycontin years ago and had anxiety with it.  I have always been diagnosed with generalized anxiety disorder and have been on lexapro, xanax,and klonopin.  The klonopin worked the best for me.  I went on methadone about 2 yrs ago and my PM doc said he did not think I should take the klonopin with the methadone.  It was not hard to just stop because I was not on any fixed amount.  I only took it as needed.  Mostly at bedtime to stop my legs from going wild.  Most times I would feel like jumping out of my skin at night.  The klonopin fixed it.  I started taking the methadone and stopped the klonopin.  Funny thing happened , I noticed the methadone not only fixed my pain but also helped with anxiety.  It seemd to keep me even and I slept great.  Now, since I have been forced to stop taking the only thing that has helped me by the Florida legislators I am back full force with my anxiety.  I am now on the morphine cr and my legs go crazy at night,  I feel like jumping out of my skin during the day,  I just feel down right anxous.  I hate it.  My Primary care doc has always offered to give me an anti anxiety med If i needed it but I have always been hesitant because of my meds.  Here are my questions and understand I know we are not doctors (most of us anyway) so these are just comments.  Are some pain meds better than others when adding anti anxiety meds?   I have always heard never ever ever ever mix methadone and xanax!  Is it just as bad to add morphine cr and xanax?  I imagine because methadone has such a long half life that it is not good to add it to anti anxiety meds.  I can tell you that I know the half lifes of these meds are different.  When I took the methaone I know it stayed in my body longer because I felt the pain relief much longer.  THe morphine pain relief just shuts down at about the 7th hour and I hate it.  Are some anti anxiety meds better than others?  Is valium or ativan better to add to a pain med than xanax?  Are any of you on a mixture of pain meds and anti anxiety meds?  I will be seeing my Primary doc next week and will be discussing all this with him.  I may ask if its time to add a small dose of something for anxiety.  I will not take lexapro , paxil etc.  because it completely shuts down my sex life.  I just dont want to be like one of these stars you see on tv that has died because of med interaction.  Anyway,  any comments would be appreciated and I will take them only as comments and not medical advice.  Thank you all and may your life be pain free.

Veteran Member

Date Joined Jul 2008
Total Posts : 2317
   Posted 11/3/2010 7:31 AM (GMT -6)   
Yes, I've been told that you have to be very careful with what you mix with methadone because of the risk of a heart arrhythmia. Klonipin is technically an anti-convulsant. I know that I take Lyrica (another anti-convulsant) and Methadone together. My doctor said that taking only 15mg Methadone with 50mg Lyrica is only moderately risky. Maybe with the amount you were taking it would be higher.
I would ask your doc about what you can mix with morphine. A pharmacist might also be able to tell you what interacts with what and suggest what would be a safer alternative is two particular meds don't mix. However, I would imagine morphine would be much safer on many levels. I don't know for sure, but just the fact that morphine tends to be used commonly after surgeries & they administer it together with all kinds of meds makes me think it's probably safer to mix. But perhaps that only applies to the short-term.
I sure hope they can get you something soon to help you feel better. That is just so lousy that your doc stopped prescribing the one med that worked for you.


Veteran Member

Date Joined Jul 2009
Total Posts : 2042
   Posted 11/3/2010 7:43 AM (GMT -6)   
There are web sites that you can check drug interactions. Some are stand alone and others are part of a pharmacies web site. Just google drug interactions.

Now just because something comes up with a potential interaction does not automatically mean that the combination is a no go. It is just something to be aware of and make sure you discuss it with your doctor as the benefits might outweigh the potential risks.
2 confirmed herniated lumbar discs. Spinal Arthritis. Spinal Stenosis, diabetic peripheral nueropathy.

Regular Member

Date Joined Mar 2010
Total Posts : 186
   Posted 11/3/2010 8:50 AM (GMT -6)   
Hi Shaw,

I take morphine cr, norco and for anxiety i take xanex. i have not noticed any problems. I also take Celexa as my everyday anxiety med.
I am a 29 yo female, Dx with UC in 97, hospital stays monthly, tons of blood transfusion, bowel rest on TPN, prednisone, asacol, sulfa, imuran, VSP
99- multiple failed remicade treatments, more hospital stays
finally in 2001 had enough and had total colectomy (j-pouch) surgery, 1st step was good, then the reversal was not such a breeze, got peritinitis which was awful!!
the rest of 2001-2006 were amazing!
now having problems again- they are thinking Crohns.- have been on Humira with no luck
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