Eric, I was started at 60mg one time per day and that lasted for about a month. I now take 60mg 2X per day - once in the morning and once at night.
I saw definite benefits at this level and have been able to maintain a steady 4/10 on the pain scale (as long as I take all my other meds as scheduled, and I am on other pain meds). My doctor and I have a great relationship and we talk through every change in my meds - why the change should happen, what I can expect, etc.
Every drug reacts differently for every person. When I first started on Cymbalta, I had three days of the most horrific nausea I've ever experienced (which is scary for me, as I am unable to physically vomit, due to a surgery for my GERD). I honestly thought I was going to die and for those three days, I did nothing but sit as motionless as possible on the couch. On day 4, I woke up and felt great. No nausea, no after affects, no major pain....it was pretty cool.
I hope you find relief with the Cymbalta. I tried Lyrica first and the side effects for me were terrible - weight gain like crazy, dizzy, vision problems, hallucinations...you name it. With Cymbalta, I've had nothing negative since those first three days, so it's been a God send for me.
DX: Fibromyalgia, Severe Myofascial Pain, Chronic Pelvic Pain, Surgical Adhesions, IBS, IC-PBS, Carpal Tunnel (both wrists), FAI, Diabetes (just diagnosed), Reynauds, Opthalmic Migraines, Drug Related Hot Flashes, Hard Start for IV's, Unable to vomit due to surgery.
Meds: Oxycontin, Tramacet, Cymbalta, Cesamet, Flexeril, Clonidine + Vitamin D + Multi daily