Most non-binding opioid

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Medicalkid2
Regular Member


Date Joined Oct 2010
Total Posts : 147
   Posted 11/14/2010 12:39 AM (GMT -6)   
Ok so I'm going to see a new GI and maybe probably a pain doc. I'm just curious about something I noticed. Hydrocodone binds me up (constipation) ALLOT more than oxycodone ? Has anyone else noticed this? I understand stuff like darvocet isn't as binding but I'm not sure that'll hit this pain as 10mgs of some lortabs I had left from a broken limb barely do it :/ so basically I'm asking would an equal dose of a strong narcotic and a week narcotic have equal binding effects as well? 10-15 mgs of lortab is fine if it lowers the pain but if you have crohns you have to watch it. Which is better lower dose of oxy or higher dose of hydro? I'm curious for my own sake and just for my own interest level as I'll be pre med soon.

Jim1969
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Date Joined Jul 2009
Total Posts : 2042
   Posted 11/14/2010 6:39 AM (GMT -6)   
Everyone reacts differently to medications and where one person will have a devil of a time with side effects another person will have few or none.
2 confirmed herniated lumbar discs. Spinal Arthritis. Spinal Stenosis, diabetic peripheral nueropathy.

Screaming Eagle
Veteran Member


Date Joined Sep 2009
Total Posts : 5005
   Posted 11/14/2010 9:24 AM (GMT -6)   
 
      Hello!
 
        I will suggest a very simple treatment that PaLady suggested several times here on the forum.
 
           Prunes! smilewinkgrin   All natural and works well for many people. I still eat them from time to time, but not as much since I'm on a lower dose of oxycodone.
 
       SE wink

cogito
Veteran Member


Date Joined Oct 2010
Total Posts : 932
   Posted 11/14/2010 2:33 PM (GMT -6)   
Just to illustrate how different reactions to opioids can be...

I use Ultram ER 300mg daily with mostly hydrocodone (10-15mg) for breakthrough. I've also used oxycodone, oxymorphone, hydromorphone and nucynta.

I was constipated during my first week or so of using Ultram. But now, only Nucynta (which I use for evening break-through) causes me to miss my morning post-coffee BM.

My wife uses citrucel every night and when I have been constipated, I've done the same. Extra fiber is good for most people and perhaps you should give it a shot. There is also miralax which can soften stool by increasing the volume of water. I once tried ducolax, but that caused me immense intestinal pain!

If you haven't yet tried them, perhaps give citrucel or miralax a shot before modifying your meds. Strong coffee (or as another poster noted, prunes) can also do the trick.

Screaming Eagle
Veteran Member


Date Joined Sep 2009
Total Posts : 5005
   Posted 11/14/2010 4:00 PM (GMT -6)   

 

      Cogito, I thought it was interesting that you mentioned the Miralax increase in water volume. It is a good point to make, and I think I did read a published report somewhere about it. That being said, there was a concern about it drawing too much water away from other tissue in the body if it was over used. It sounded like a catch twenty/two to me. Have you read anything like this or am I all wet here smilewinkgrin  I thought your reply was insightful, but I just wanted to know more about the increase of water volume to the stools. Is this only from the intake or does it actually draw the water volume from the surrounding organs and tissue?

   Thanks!

   SE wink   

Post Edited (Screaming Eagle) : 11/14/2010 2:10:07 PM (GMT-7)


spinal soldier
Veteran Member


Date Joined Dec 2009
Total Posts : 687
   Posted 11/14/2010 8:42 PM (GMT -6)   
hello, thats a good question, the smooth muscle relaxing effects of opioids is what brings on the constipation so technically the more potent is worse but, if you are taking generic hydrocodone tablets that are a good product as opposed to a sup-par generic percocet probably hydrocone is worse but the oxycodone if bioavailible is worse i think. morphine and methadone seem to be some of the worse and long-acting opioids are bad.
L4,L5,S1 bilateral Laminectomies, Foraminotomies 2002
L4-S1 PLIF with instumentation 2008,

current Rx: morphine sulfate ER 10OMg q8 , roxicodone 30-60mg prn,vistaril50mg prn nausea, Lyrica 150mg 2x,Adderall 20mgs 1x A.M. 10mg PM prn, Soma 350 mg 3X, Relafen 1000mg 1x, alprazolam o.5 mg, Supplements: CO-Q10 100mg, Vitamin D 2000IU, Fish-Oil1000mg EFA, B-Complex50 3x/day, GABA 750mg,

golitho
Veteran Member


Date Joined Sep 2008
Total Posts : 1670
   Posted 11/14/2010 8:48 PM (GMT -6)   
I'm not a huge prune eater but I eat dried apricots and lots of water and this seems to do the job for me.
My trouble is they can be addictive!
But if you don't like prunes, dried apricots is an alternative. golitho

ReactiveConstellationNE
Regular Member


Date Joined Dec 2005
Total Posts : 256
   Posted 11/16/2010 4:51 AM (GMT -6)   
The different opioids behave very differently in the digestive tract and therefore can have wide variation in their effect on the nervous system versus their relative tendency to cause constipation. Also, digestive systems and individual absorption of opioids varies widely from person to person -- moreso than most docs will bother to acknowledge or take into account, so you have to be mindful of this.
Conditions: Reactive Arthritis (AKA Reiter Syndrome), Crohn's Disease, Chronic Pelvic Inflammatory Syndrome, Sacroiliitis, Costochondritis, As Yet Unknown MS-Like Relapsing/Remitting Neuropathy, and a partridge in a pear tree.

Medications: Currently not that many are taken daily, but there are many at my disposal for part-time use. Low dose pain medication, after years at high doses. Working on innovative ways of taking lesser-known pharmaceuticals and non-prescription supplements to maximum benefit.
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