Topical Use of Opioids

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Veteran Member

Date Joined Oct 2010
Total Posts : 932
   Posted 2/1/2011 2:39 PM (GMT -6)   
Someone recently posted a link to and I was reading the information related to the topical use of opioids (

My most serious problem with opioid use is that I cannot take any past 5pm without it compromising my sleep that night. I am part of the 10% or so who don't get groggy and even 6 hours after taking 10mg of hydrocodone, 5mg of oxycodone, etc. won't be able to sleep.

So, I'm now curious about topical use and thought I would give it a try. I'll discuss it with my PM, but wonder if anyone here has had any success?

If so, for what conditions, what opioid, and how was it prepared for topical use?
I have scoliosis, extra oxymorphone and a jar of DMSO. My thought was to follow the research data related to preparation and apply it to the skin from my spine out to the various muscles that get into spasm due to nerve root impingement. So, about an 8inch by 10inch area. Probably will start with a smaller quantity to test for skin reaction first.
C4-T4 Scoliosis (disk degeneration, stenosis, narrowed neuroforamen, bone spurs)
RT hip and SI joint damage from car accident
Current meds: Ultram ER 300mg daily, breakthrough - hydrocodone 10-15mg, or oxycodone 5-7.5mg. .5mg ativan as needed for sleep.

Veteran Member

Date Joined Jul 2008
Total Posts : 2317
   Posted 2/1/2011 4:17 PM (GMT -6)   
Topical caused the same CNS problems as orals, in my experience.

good luck, though!

Veteran Member

Date Joined Apr 2009
Total Posts : 856
   Posted 2/2/2011 7:42 AM (GMT -6)   
Definitely talk to your doctor about it first.

Regular Member

Date Joined Aug 2010
Total Posts : 215
   Posted 2/2/2011 12:09 PM (GMT -6)   
Topical opioid treatment was believed to provide longer lasting relief and less addiction. I know it was being throughly researched, and to my knowledge fentenyl and subutex (bupe in a patch), were the only approved products to my knowledge. I hope they research it thouroughly and perhaps trying using some plany opiates like Kratom. Kratom has mild opioid effects but the actual chemical that causes the MOR receptor effect is actually very powerful, its just that the dosing is very low and almost sub theraputic within the plant leaf.
MRI revealed disc bulge and test injections revealed RA. Radio Freq procedures have decreased the severity of pain by about 1/3rd. currently on 75 mgs of Nucynta (tapentadol) 3 time per day. Works as well as 10 mgs of hydrocodone, less addictive, no tylenol, but schedule II. Also take Alieve OFTEN, much better than Ibu.
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