I use different meds for fibromyalgia and post-op pain. It took a long time to find that tramadol works well enough on fibro muscle pain since I have had a number of surgeries while trying out various meds for fibro. I use Vicodin for post-surgical pain. Those are the only pain meds I can take without taking Zofran for severe nausea.
Tramadol helps with my spinal arthritis, radiculopathy pain and sciatica, but I'd like to have something better. It seems not to help as much with skin, organ and bone or tendon pain, but it's better than NSAIDs or nothing.
I don't dare take Zofran along with tramadol or I start getting clonic muscle spasms - twitches. I had to switch over to Vicodin during breast cancer radiation treatment because I needed Zofran to control rad nausea.
I have to beware of taking Vicodin along with tramadol, because it can trigger serotonin syndrome too. Tramadol causes higher serotonin levels all on its own, which explains why I feel a better mood when it kicks in. The twitches are a warning that serotonin syndrome is starting. If I ignore that, I start getting a problem with controling temperature, can turn beet red and sweating.