I've been on prednisone for a long time and have also had problems with restless leg syndrome, but in my case I don't believe there was any connection between the two. But you should definitely ask your doctor about the RLS because he/she would know better than I, plus there are medications that can help you. I too have liver issues (from autoimmune hepatitis) but have been able to take two of the meds for RLS in the past when I needed them. I now use a CPAP because of sleep apnea and I no longer seem to have issues with RLS.
Lyme Disease, Babesiosis, Ehrlichiosis, Bartonella, AIH, Hashimoto's, lupus, fibro, RA, celiac, asthma, psoriasis, adrenal fatigue, pre-diabetic, Raynaud's, hypertension, osteopenia, sleep apnea, RLS, GERD, DDD, severe lower back pain, cubital tunnel, tarsal tunnel, Suprax, Malarone, Alinia, Zithromax, Prednisone, Imuran, Plaquenil, Lyrica, Cymbalta, Levothyroxine, Liothyronine, Atenolol, Cozaar, Zyrtec, Fosamax, Albuterol, Prilosec