they have no evidence backing drug-holidays as good. maybe some benefit but if you are on methadone that is the worst because it may take a month to withdraw due to how it stores up in bone, fat, muscle, and has a long half-life. i have seen studies rotating to buprenorphine at a pain control dose for a few months might down-regulate your receptors. methadone is a problem with that because it is hard to make that change. Have you tried generic Opana IR? Levorphanol tartrate "levo-dromoran" might be an option because like methadone it antagonizes the NMDA receptor/Glutamate receptor which they believe plays a role in tolerance. med rotation may be a better alternative to the hell of methadone w/d. potentators or adjuvants like Elavil or Vistaril or Soma may get more out of the opioid. the amino-acid DL-Phenylalanine may help, but you are getting into areas where a pain specialists is needed.
L4,L5,S1 bilateral Laminectomies, Foraminotomies 2002
L4-S1 PLIF with instumentation 2008,
current Rx: MScontin 100mg q8hrs. , dilaudid 8mg q6hrs. prn, oxymorphone IR 10mg q6 ,vistaril 50mg prn nausea, Lyrica 150mg 2x,Adderall 20mgs 1x A.M. 10mg PM prn, Soma 350 mg 3X, Elavil 25 HS, diazepam 10mg bid prn, Supplements: CO-Q10 100mg, Vitamin D 1000IU, Fish-Oil1000mg EFA, B-Complex50 3x/day, ALA