oxycodone and hyperalgesia?

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spinal soldier
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Date Joined Dec 2009
Total Posts : 687
   Posted 4/26/2011 10:55 AM (GMT -6)   
has any one observed oxycodone has more of a chance of getting your receptors all worked up after long term use? Oxycontin, Roxicodone, Percocet, Tylox/OXY-IR another way of asking is have you noticed more of a smooth, level effect with other opioids: Morphine, Oxymorphone, Hydromorphone, ect.?

Veteran Member

Date Joined Apr 2010
Total Posts : 2261
   Posted 4/26/2011 10:51 PM (GMT -6)   
Hi. I'm on plain oxycodone now and i've been on morphine in the past and i don't see a difference. Remember, people are wired differently and can have different side effects and things happen with different meds. I hope that helps. Take care. I hope you're having a low pain night.

love and hugs
Dx: osteoarthritis, bursitis in left hip, Osteoarthrits in right hip, compression fracture in thoracic spine due to falling on frozen ground March 2001 , ddd, spinal stenosis, bone spurs, osteoarthritis in spine, osteoarthritis in both knees
Meds: Fentanyl patch, oxycodone, otc: BenGay, Tylenol Arthritis on occasion

Backpain Sara
Regular Member

Date Joined Apr 2011
Total Posts : 30
   Posted 4/28/2011 8:57 AM (GMT -6)   
Hi Soldier-I started on MS Contin then went to Oxycontin and found there wasn't any difference with one causing more pain but taking MS Contin for 2 years my Dr. switched me to Oxycontin about 1 year ago. I've gone from 120 Oxy to 60mg as I was concerned about that also but sometimes I take 70 or 60mg if pain level is high. I don't think I have hyperalgesia from Oxycontin. Sara
Chronic back and leg pain. Degenerative disc disease for 3 years and unable to work since injuring my back. EMG/nerve test shows peroneal sciatic nerve is being irritated from L4-L5 disc area. Meds-Oxycontin, Cymbalta, lyrica, flexeril,Wellbutrin, Oxazepam for sleep. TX-facet joint, trigger point, nerve block and epidural injections every year x 3 years with temporary relief only. Did PT.

Veteran Member

Date Joined Sep 2006
Total Posts : 1713
   Posted 4/28/2011 9:54 AM (GMT -6)   

No, I haven't noticed either. I take ocycodone and have for years. I have tried Morphine and Oxycontin, Avinza and many many other long acting medications, but they all give me side effects and truly don't work as well as the oxycodone.

Recently I switched from Percocet to plain Oxycodone and have noticed that I need some ibuprofen sometimes in addition to the oxycodone, but other than that, no hyperalgesia.

Thank you for the post. Good one.

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