Levorphanol/Levo-Dromoran?

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

spinal soldier
Veteran Member


Date Joined Dec 2009
Total Posts : 687
   Posted 5/21/2011 11:34 PM (GMT -6)   
is levorphanol currently available in the USA pharmacopeia? it was available in 2 and 4mg conventional release tablets under the brand name Levo-Dromoran? i think that may be a worth a try because for chronic pain that morphine or hydromorphone or oxycodone, oxymorphone or fentanyl won't give good relief, which are all primarily mu-recptor agonist, Levorphanol has the potency of Dilaudid or Opana or 6-8 times more potent than morphine, but many more properties of levorphanol are chronic/intractable pain modulating although the primarily mu-agonist selective like morphine or fentanyl do not have a bonus of potent pain controlling actions. Levorphanol has potent NMDA receptor antagonism effect which is thought to stop tolerance from being a big deal and is similar to Methadone in this effect. it also may have direct pain controlling action by antagonizing the NMDA receptor and blocking the excitatory neurotransmitter glutamate from revving you up pain is helped. Levorphanol is a potent mu-receptor agonist but also has strong affinity to the kappa -opoid receptor and the delta-opioid receptor and is a full agonist on all. Also it has medium SSRI and SNRI actions which controls pain on the descending pathway like Cymbalta or Nucynta or amitirptyine, really most tricyclics and most SNRIs or SSRIs or the NRIs or NDRIs. i think Wellbutrin is a NDRI and Strattera or Provigil are NRIs. lastly it has sigma-receptor agonism like Lamictal has and the active life of the immediate release version is 6-8hrs. compared to immediate release versions of morphine, dilaudid, or oxycodone is 2-4hrs. Oxymorphone IR/OPANA IR is the only IR pill with a 5-11hr. life but is only 10% orally absorbed and 80-90% IV OR Intrathecal. Levorphanol is equally strong orally or parentarly(IV,IM). in fact it might be better than that like 2:1 oral/IV,IM. to me it is the only thing left to trial for my spine pain/neuropathy in foot that may really help with the stress, depression, anxiety, and ever increasing doses of morphine,opanaIR,and dilaudid with 8 or 9 add ons like Lyrica ect. has anyone used it with a review or recently found available at a drugstore? God bless, good night. idea

Screaming Eagle
Veteran Member


Date Joined Sep 2009
Total Posts : 5005
   Posted 5/22/2011 12:10 AM (GMT -6)   
SS!..I have read this 20 times already....and for the life of me!...I guess my IQ...does not even register on the IQ meter tonight! smilewinkgrin

One thing I wanted to point out,.. is to be careful in making statements like.... "i think that may be a worth a try because for chronic pain that morphine or hydromorphone or oxycodone, oxymorphone or fentanyl won't give good relief"

Many of the members here do indeed find good relief with many of these med's, so we need to be careful in making a blanket statement like this. Everyone is different in how well they do on certain med's.

While I'm not familiar with the med, you have a question about, I'm sure someone here will recognize it, and reply back to you soon.

Take care,

SE
Moderator Chronic Pain Forum

Weekly Quote!

"Snowflakes are one of nature's most fragile things, but just look at what they can do when they stick together"

CRPSpatient
Veteran Member


Date Joined Mar 2011
Total Posts : 1276
   Posted 5/22/2011 3:12 AM (GMT -6)   
SE... I think SS is saying that Levorphanol may be valuable for CP patients who don't find good relief with the aforementioned meds, rather than saying that the meds don't provide good relief for CP :)

It certainly sounds interesting, particularly if it has NMDA-antagonist properties. I know that methadone gave me some of the best pain relief I've ever experienced - I suspect for that very reason - but the nausea/vomiting side effects were intolerably severe.

Fascinating post all up - thank you for sharing!

Laura
CRPS since 1999, diagnosed in 2005 and since spread to full body, spasms, dystonia & contractures, gastroparesis, orthostatic hypotension, bursitis, carpal tunnel syndrome.

On Oxycontin/Endone, Topamax, Mobic, Magnesium, Florinef, Somac, Cipramil. Have a spinal cord stimulator, intrathecal pump with baclofen & bupivacaine and doing physio.

Screaming Eagle
Veteran Member


Date Joined Sep 2009
Total Posts : 5005
   Posted 5/22/2011 3:51 AM (GMT -6)   
Laura, Yes you may be right!.....lots of technical wording that many of the members may not understand. Most of us do not have the pharmaceutical education that SS has.

It's way over my head, but I suppose that doesn't take too much! wink

I did reread it again, and I do believe you are right on the intent. My apologies! We have at times had more than one member make blanket statements, saying that certain med's were absolutely worthless, with no regards to members opinion's and or facts.....so I suppose I read something into it that was not intended. Good catch! wink We certainly want SS to express his opinion's freely, in hopes that it may help a member and or visitor looking for a suitable treatment.

Have a great evening!

SE wink
Moderator Chronic Pain Forum

Weekly Quote!

"Snowflakes are one of nature's most fragile things, but just look at what they can do when they stick together"

Post Edited (Screaming Eagle) : 5/22/2011 2:57:15 AM (GMT-6)


Snowbunny21
Veteran Member


Date Joined Jan 2010
Total Posts : 3557
   Posted 5/22/2011 11:36 AM (GMT -6)   
I think what is confusing is it looks like most of the information is cut/pasted from a website that explains in detail what the medicine is and how it works...and then SS adds in a few statements about how it may be beneficial to some..

I agree that it's best to work with our Dr.s since we all have different types of pain and pain generators, that require certain medicine to help us.

It's always interesting to read about all the varying medicines out there to help with pain..That is a great thing since sometimes people have allergic reactions or side effects too great to continue something, so it's good to have other choices to help alleviate our pain..

So SS...maybe you can discuss this with your DR. at your next appt. to see if it's something they would think might be useful to help with your pain..


Keep us posted..
SB and "the pup who snores loudly" 
 
ACDF C5-C7, (no hardware), with autograft bone Nov. 2001
(reabsorption of bone 2 years later...still lost in body..expect to burp it out at anytime..haha")) 
ACDF with hardware, allograft bone Nov. 2005 
Anterior and Posterior CDF, allograft bone with BMP, removal of old hardware, use of titanium plates, rods, screws, & kitchen sink (lol) Oct 2006
 
 
New Topic Post Reply Printable Version
Forum Information
Currently it is Tuesday, September 25, 2018 1:50 PM (GMT -6)
There are a total of 3,006,508 posts in 329,346 threads.
View Active Threads


Who's Online
This forum has 161835 registered members. Please welcome our newest member, scattycatty.
352 Guest(s), 16 Registered Member(s) are currently online.  Details
Mustapha, 81GyGuy, mattamx, island time, adartist12, sebreg, Anitas, Admin, zack36, Darla, Serfr, Alex ArmPain, Squarsh, garyi, Envsciguy, Estarnes