Stopping the Amitriplyne

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Jim1969
Veteran Member


Date Joined Jul 2009
Total Posts : 2042
   Posted 8/18/2011 4:39 PM (GMT -6)   
It's been a week since I started taking this drug in hopes of it helping with my diabetic nerve pain, and quite frankly it has been a week from hell.

This drug keeps my up for about 2 days straight and then knocks me out for 15-18 hours, and then when I finally am able to drag myself out of bed I am very disoriented and can barely stand or walk for several hours. As if that isn't enough I have noticed a significant lack of patience with anything. The slightest thing makes me angry and even when there is nothing at all to irritate me I still feel agitated, irritated, grumpy, with an undertone of hostility.

I can't live this way. I have too many responsibilities in caring for a 6 year old including taking him to school and picking him up everyday, not to mention it isn't fair to him having me get mad at the least little thing he does wrong or that I simply don't like.

Screaming Eagle
Forum Moderator


Date Joined Sep 2009
Total Posts : 5005
   Posted 8/18/2011 4:52 PM (GMT -6)   
Hello Jim!

Sorry to hear of this setback, and it does not surprise me, as I have read of several members who have struggled with this med.
Lets hope you get back to somewhat of your normal self, and then maybe try something else once it has cleared your system.

Take care,

SE
Moderator Chronic Pain Forum

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Retired Mom
Veteran Member


Date Joined Feb 2010
Total Posts : 1753
   Posted 8/18/2011 4:57 PM (GMT -6)   
Hello Jim,

I have never taken that particular medicine, but I can certainly relate to your situation. You seem like a wonderful person to be so concerned about your temperment with a six year old. You're so right and so on target. I hope you will find relief very soon from the pain that you suffer (without the nasty side effects).
TLIF L5-S1/failed, Pituatary disorder w/HGH deficiency, Fibro, Failed Bladder Surgery & Nissen, GERD, OCPD, GAD, MDD, CFS, TMJ, Migraines, Pre-glaucomic, HBP, Idiopatic Reactive Hypoglycemia w/Diabetic reaction to HGH, Bi-lateral CTS (surgery related trigger finger), Edema, Tarsal Tunnel Syndrome, Peripheral Neuropathy, Plantar Fascitis, Tibular Tendionitis, Adult Onset Flat Feet & much more.....

CRPSpatient
Forum Moderator


Date Joined Mar 2011
Total Posts : 1276
   Posted 8/18/2011 5:57 PM (GMT -6)   
Hi Jim,

I can relate to some of your side effects for sure. My doctor put my on amitriptyline to help with my CRPS pain and to help me sleep. I didn't have the long periods of being knocked out that you have had, but being up for 2 days straight - yep. I was completely wired, very anxious - I could probably have achieved the same effect by downing half a dozen double espressos. The nastiness too... I was living in my own place at the time and remember Mum telling me on a visit home that it was just as well - because I was so bad that if I'd been living at home she'd have thrown me out...

I hope that you can find relief soon

Laura
CRPS since 1999, diagnosed in 2005 and since spread to full body, spasms, dystonia & contractures, gastroparesis, orthostatic hypotension,bradycardia/tachycardia, bone spurs, bursitis, carpal tunnel syndrome.

On Oxycontin/Endone, Topamax, Mobic, Magnesium, Florinef, Midodrine, Somac, Cipramil. Have a spinal cord stimulator, intrathecal pump with baclofen & bupivacaine and doing physio.

straydog
Forum Moderator


Date Joined Feb 2003
Total Posts : 16303
   Posted 8/19/2011 12:45 PM (GMT -6)   
Hi Jim, Amitriptilene is the generic for Elavil. Its an anti-depressant but used off label like everything else. I was put on it for migraines and I could not tolerate it either. I had been hospitalized for a week because of a migraine and was on a low dose while in there. All I did was sleep. When I was discharged my neurologist increased the dosage. That that night I took it. The next morning I tried to get out of bed and stand up, the floor literally flew up and hit me in the face, at least that is what it felt like to me, lol. I flushed them and called her and said no more for me. Believe it or not if you can tolerate it, it can do wonders for people that suffer with migraines.

My son has migraines that started at the age of 8 with projectile vomitting. His neurologist put him on the lowest dose of Elavil for 30 days and managed to break the pain cycle. It made a huge difference in his migraines at that time. And he had no side effects to the drug at all.

It was also the drug of choice with RSD/CRPS was first diagnosed in people as well. Its one of those things either a person can or cannot tolerate the stuff. I hope they can find something that will help you.
Moderator Chronic Pain Forum

Potsie
Regular Member


Date Joined Oct 2009
Total Posts : 291
   Posted 8/19/2011 5:03 PM (GMT -6)   
I take it and have been for about a year. No side effects at all. It helped me through my husbands illness and death, also my own illness. So sorry you are having problems with it!!

Jim1969
Veteran Member


Date Joined Jul 2009
Total Posts : 2042
   Posted 8/19/2011 6:08 PM (GMT -6)   
What I am hoping is that now that I have tried it and have reported some really nasty side effects the state will approve me going back on Cymbalta.

I have been on many different medications over the years for this, that or another and have never had a reaction like I did to this drug.

It has been almost 48 hours since my last dose and the hostile feelings have been going away. I still feel some and some agitation but nothing like I did yesterday.

I talked to one of my doctor's nurses today. They had finally called me back about an email I sent in reporting the side effects on Monday evening. She said the doctor wanted me to continue with it for another week and I told the nurse that the side effects had increased dramatically in the last couple of days and that it was bad enough to be both debilitating and dangerous to those around me and that under no circumstances was I going to take any more. She asked when I had my last dose and how I was feeling now. I told her it was Weds night and that I am starting to feel more in control. The nurse said she would pass it on to the doctor.
2 confirmed herniated lumbar discs. Spinal Arthritis. Spinal Stenosis, diabetic peripheral nueropathy.

CRPSpatient
Forum Moderator


Date Joined Mar 2011
Total Posts : 1276
   Posted 8/19/2011 6:57 PM (GMT -6)   
Hi Jim - just a thought, and not sure if it will do you any good -

If even after this you are still having trouble getting approval to go back on the Cymbalta, it might be worth approaching the drug company directly - many of them have a 'compassionate supply' program. I'm in the process of doing that very thing with my Topamax because I'm having trouble with the costs (more than $100/month, and going to go up because I've just increased my dose). It's a matter of applying for a form and getting your doctor to fill it out, then submitting to the company and hoping that they approve.

Laura
CRPS since 1999, diagnosed in 2005 and since spread to full body, spasms, dystonia & contractures, gastroparesis, orthostatic hypotension,bradycardia/tachycardia, bone spurs, bursitis, carpal tunnel syndrome.

On Oxycontin/Endone, Topamax, Mobic, Magnesium, Florinef, Midodrine, Somac, Cipramil. Have a spinal cord stimulator, intrathecal pump with baclofen & bupivacaine and doing physio.

Jim1969
Veteran Member


Date Joined Jul 2009
Total Posts : 2042
   Posted 8/19/2011 8:07 PM (GMT -6)   
It's a good thought Laura, been there done that already though.

Since I have "insurance" the manufacturer will not cover it.
2 confirmed herniated lumbar discs. Spinal Arthritis. Spinal Stenosis, diabetic peripheral nueropathy.

NiNi53
Veteran Member


Date Joined Mar 2011
Total Posts : 816
   Posted 8/19/2011 8:15 PM (GMT -6)   
Hi Jim, I think I have said this before, but I will never take amitriplyne again ever.  This left me in such a fog, I didnt know what was real and what was not.  I notice more people have bad side effects then not having a problem with the side effects.
 
For several years, I was given scrips for them, after the first, I never filled another.  If you wonder why I took the scrips at all, its because they insisted I take this antidepressent, again blackmail, if you dont get this, your not going to get your pain meds.  So month after month I was given a prescription for it.  As soon as I left the dr office they were ripped up and thrown away, and month after month I was asked how they worked, I said fine.  I had run gambit of antidepressents, not one worked.  So it was just easier to let them think they were doing just great.  They just didnt listen, and I needed the pain meds for my pain so.
 
Of course the good thing is the doctor I have now, he did listen.  He is great and I hope to be with him well a very long time.
 
Take care, good luck with the cymbalta.
 
Kathy
degenerative disc disease, fibromyalgia, osteoarthritis, neuropathy, lumbar laminectomy july 1998 no help, rechargeable neurostimulator unit low right back w/lead wires to left side and right leg unit not working just sitting there.i am 57 years young in may will turn 58. i have 2 grown daughters, 25 and 29. i have 2 grandchildren, 9 year old grandaughter and 5 yr. old grandson

chanterelle
Regular Member


Date Joined Apr 2011
Total Posts : 99
   Posted 8/19/2011 8:43 PM (GMT -6)   
Oh, man!  I was on Ami for only 6 days (prescribed for insomnia due to pain) and that was one of the most nightmarish times of my life.  It kept me awake for the entire time - I did not even fall asleep for all those days and nights.  Not once.  I felt like an entirely different person (as SE can attest to!).  It was difficult walking.  My mind was impaired.  I could not think clearly.  Obviously a lot of that was due to sleep deprivation but that was caused by the medication.  My husband was very worried about me.  It was so horrid.  I've tried many prescriptions to help with pain and never did I feel even remotely close to that whacked out.  Ever.  You could not pay me to try them again! 
Back injury 2007 with 3 herniated discs, IT band syndrome, myofascial pain, DDD.
Rotator cuff injury both shoulders.
Diagnosed with Celiac Disease February 2011.
Diagnosed with Fibromyalgia April 2011.
Insomnia forever but worse the past few years due to pain and discomfort.

grandmaroses
Veteran Member


Date Joined Jan 2011
Total Posts : 1355
   Posted 8/19/2011 10:30 PM (GMT -6)   
Holy moly what terrible side effects, sorry you had to go through this. I take amitriplyne and have not noticed any difference with my current dose. My dr had me double it but I had too hard of a time waking up so I went back to the original. I also take cymbalta and for me I notice it reduces some of my pain and I am not having panic attacks. Good luck Jim I hope you manage to get your cymbalta Rx back.
Take care
Rose



Insulin Dependant Diabetic, Fibromyalgia, Gerd, IBS, Sleep Apnea, COPD, Spondylolistesis, Diabetic Neuropathy, Fatty Liver, High Cholesterol
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